Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease

Table 3 Changes in the mean fluorescence intensity of surface multipotent mesenchymal stromal cell antigens during co-cultivation with peripheral blood mononuclear cells expressed as the fold change relative to multipotent mesenchymal stromal cells cultured without peripheral blood mononuclear cells

Time of co-cultivation	1 d		4 d
Group of MSC samples	Effective	Ineffective	Effective	Ineffective
HLA-ABC	1.90 ± 0.11	1.53 ± 0.30	1.90 ± 0.15	1.67 ± 0.33
CD90	0.95 ± 0.04	0.79 ± 0.061	0.55 ± 0.04	0.49 ± 0.10
HLA-DR	134.37 ± 63.90	654.74 ± 363.49	682.42 ± 326.38	151.88 ± 96.44
CD105	1.08 ± 0.06	0.98 ± 0.14	0.64 ± 0.05	0.42 ± 0.07
CD146	0.82 ± 0.07	0.86 ± 0.30	22.16 ± 16.28	0.81 ± 0.21
CD54	60.59 ± 12.29	44.76 ± 8.84	33.08 ± 5.30	23.19 ± 7.64
CD274	434.64 ± 93.56	1.27 ± 0.281	573.44 ± 172.78	319.25 ± 233.40
CD73	1.05 ± 0.08	0.56 ± 0.131	150.36 ± 103.94	1.60 ± 0.54

¹Significant differences between effective and ineffective samples. MSC: Multipotent mesenchymal stromal cell.