Role of platelets and breast cancer stem cells in metastasis

doi:10.4252/wjsc.v12.i11.1237

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Nov 26, 2020 (publication date) through Dec 23, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2020; 12(11): 1237-1254
Published online Nov 26, 2020. doi: 10.4252/wjsc.v12.i11.1237

Table 1 Therapeutic targets related to breast cancer stem cell pathways and platelet content

Breast cancer	Target/Pathway	Treatment Phase	Drug name	Ref.
BC	CXCR4	-	Plerixafor	[136]
BC	TGFß	-	Trabedersen	[137]
BC	DDL4/Notch	I	Demcizumab	[138]
BC, TNBC	Notch3	I	AntiNotch3-ADC	[139]
BC	Wnt	I	Ipafricept	[140]
BC	PI3K	I	Alpelisib	[141]
TNBC	PI3K	I	Buparlisib	[142]
MBC	CXCR1	Ib	Reparixin	[143]
BC	EpCAM	II	Adecatumumab	[144]
TNBC	Notch	II	Nirogacestat	[145]
MTNBC	JAK	II	Ruxolitinib	[146]
MBC	VEGF	III	Bevacizumab	[147]

BC: Breast Cancer; TNBC: Triple-negative breast cancer; MBC: Metastatic breast cancer; MTNBC: Metastatic triple-negative breast cancer.

Citation: Mendoza-Almanza G, Burciaga-Hernández L, Maldonado V, Melendez-Zajgla J, Olmos J. Role of platelets and breast cancer stem cells in metastasis. World J Stem Cells 2020; 12(11): 1237-1254
URL: https://www.wjgnet.com/1948-0210/full/v12/i11/1237.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i11.1237