Proteomic profiling of various human dental stem cells - a systematic review

Table 4 Proteomic studies on influence or microenvironment or preconditioning factors on human dental stem cells

Ref.	Dental stem cells	Influence of niche or microenvironment or preconditioning factors	Main findings
Dou et al[37]	DPSCs	Hypoxia	Hypoxic culture of DPSCs under 3D framework incompletely influences the proteome profile of cells. Albeit present moment hypoxic culture (1% O2 for 24 h) changed articulation of a few proteins, the in an unexpected way communicated protein represent 2.7% (57 of 2115); By and large the impact of hypoxia on protein articulation in DPSCs was not substantial
Lee et al[38]	DPSCs	Preameloblasts conditioned medium	Preameloblasts molded medium initiates the odontogenic differentiation of DPSCs and advances dentin development in vivo and in vitro Of the distinguished proteins, Cpne7 is another applicant that is engaged with odontoblast differentiation
Kim et al[39]	DPSCs	Human LOXL2	LOXL2 negatively affects the differentiation of hDPSCs and blocking LOXL2 can elevate the hDPSC differentiation to odontoblasts
Wang et al[21]	DPSCs Periodontal ligament stem cells	Osteogenic induction medium	Fewer than 5% of the differentially imparted proteins make up the close proteomic profile between osteo-induced PDLSCs and DPSCs This examination portrays the differences between osteo-induced PDLSCs and DPSCs in vitro The mineralization and migration cutoff points of PDLSCs were more noticeable than those of DPSCs, in which heat shock protein beta-1, Protein S100-A10 and S100-A11 may have an impact
Jung et al[40]	Gingival fibroblasts	Cyclosporin-A	Prx 1 may play a relevant role in CsA-induced proliferation of gingival fibroblasts
Bakopoulou et al[41]	Apical papilla mesenchymal stem cells	Stress microenvironments: Serum deprivation, glucose deprivation, and oxygen deprivation/hypoxia conditions, individually or in combination	Endothelial transdifferentiation potential as well as angiogenic paracrine activity of apical papilla mesenchymal stem cells was significantly upgraded when uncovered for a brief timeframe to combined stress microenvironments
Lin et al[42]	hPDLSCs	2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucosid	2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucosid enhanced the renewal ability and proliferative potential of hDPSCs via the AMPK/ERK/SIRT1 axis
Rani et al[43]	hPDLSCs	PVF of the horseshoe crab embryo	PVF could improve cell cycle regulatory gene expression in DPSCs as shown by the higher articulation of the considerable number of qualities considered in this investigation at various cell passages in the treated gathering contrasted with the untreated group
Laothumthut et al[44]	hPDLSCs	WSM extracted from the nacreous layer of the bivalve pinctada maxima	The human dental pulp cells cultured in nacreous WSM showed higher relative cell suitability than those in DMEM with comparative morphological appearance; Huge changes were found in the overall plenitude of 44 proteins in cells after introduction to WSM for about 14 d; They assume a job in cell adhesion, cell proliferation, metabolic process, signal transduction, stress reaction, transcription, translation, and transport
Bok et al[45]	Dental follicle derived stem cells	HUVECs	Expanded angiogenic movement in DFSC/HUVEC co-cultures may invigorate osteoblast development of DFSCs. Along these lines, the emission of angiogenic factors from HUVECs may assume a job in the osteogenic differentiation of DFSCs
Tsikandelova et al[46]	Human dental pulpal cells	FGF 8 protein	FGF8 treatment could advance endogenous recuperating of the dental mash by means of enlistment of dental pulp progenitors just as by advancing their angiogenic and odontogenic differentiation
Qin et al[47]	Human dental pulpal cells	Metformin	Metformin can incite DPC differentiation and mineralization in an AMPK-subordinate way and that this all around endured antidiabetic drug has potential in regenerative endodontics just as in other regenerative applications
Wang et al[48]	hPDLSCs	DFO	Early introduction to DFO advanced the mineralization of DPSCs and expanded autophagic action Autophagy restraint stifled DFO-prompted DPSC movement and odontoblast differentiation
Li et al[49]	hPDLSCs	SCs and its secreted vesicles	SC emission demonstrated an overwhelmingly regulatory on the development of hDPCs

DPSCs: Dental pulp stem cells; LOXL2: Lysyl oxidase like 2; hDPSC: Human dental pulp stem cells; PDLSCs: Periodontal ligament stem cells; hPDLSCs: Human PDLSCs; PVF: Perivitelline fluid; WSM: Water-soluble matrix; HUVECs: Human umbilical vein endothelial cells; DFSC: Dental follicle stem cells; DPCs: Dental pulp cells; DFO: Deferoxamine; SC: Schwann cell; hDPCs: Human dental pulp cells.