Mesenchymal stem cells as living anti-inflammatory therapy for COVID-19 related acute respiratory distress syndrome

doi:10.4252/wjsc.v12.i10.1067

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Oct 26, 2020; 12(10): 1067-1079
Published online Oct 26, 2020. doi: 10.4252/wjsc.v12.i10.1067

Table 2 The most relevant clinical trials of mesenchymal stem cell treating COVID-19 patients

NCT number	Cell type	Autologous	Phase	Sponsor
NCT04490486	UC-MSCs	Allogeneic	I	Joshua M Hare, United States
NCT04456361	UC-MSCs	Allogeneic	I	Instituto de Medicina Regenerativa, Mexico
NCT04313322	UC -MSCs	Allogeneic	I	Stem Cells, Arabia
NCT04288102	MSCs	NA	II	Beijing 302 Hospital
NCT04346368	BM-MSCs	NA	I/II	Guangzhou Institute of Respiratory Disease
NCT04366323	Adipose-derived MSCs	Allogeneic	I/II	Andalusian Network for Design and Translation of Advanced Therapies
NCT04273646	UC-MSCs	Allogeneic	I	Wuhan Union Hospital, China
NCT04349631	Adipose-derived MSCs	Autologous	II	Hope Biosciences
NCT04339660	UC-MSCs	Allogeneic	I/II	Puren Hospital Affiliated to Wuhan University of Science and Technology
NCT04366063	MSCs	NA	II/III	Royan Institute
NCT04352803	Adipose-derived MSCs	Autologous	I	Regeneris Medical
NCT04355728	UC-MSCs	Allogeneic	I/II	Camillo Ricordi
NCT04366271	UC-MSCs	Allogeneic	II	Hospital Infantil Universitario Niño Jesús, Madrid, Spain
NCT04348461	Adipose-derived MSCs	Allogeneic	I	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
NCT04345601	BM-MSCs	Allogeneic	I	Baylor College of Medicine
NCT03042143	UC-MSCs (CD362 enriched)	Allogeneic	I/II	Belfast Health and Social Care Trust
NCT04361942	MSCs	Allogeneic	II	Red de Terapia Celular
NCT04269525	UC-MSCs	Allogeneic	II	Zhi-Yong Peng, Hospital
NCT04333368	UC-MSCs	Allogeneic	I	Assistance Publique - Hôpitaux de Paris
NCT04299152	Cord blood stem cells (CB-SC)	Allogeneic	II	Tianhe Stem Cell Biotechnologies Inc.
NCT04341610	Adipose-derived MSCs	Allogeneic	I/II	Rigshospitalet, Denmark
NCT04276987	Adipose MSC-derived exosomes (inhalation)	Allogeneic	I	Ruijin Hospital
NCT03857841	BM-MSC derived extracellular vesicles (UNEX-42)	Allogeneic	I	United Therapeutics

MSC: Mesenchymal stem cells; BM-MSC: Bone marrow derived mesenchymal stem cells; UC-MSCs: Umbilical cord mesenchymal stem cells.

Citation: Lin F, Ichim TE, Pingle S, Jones LD, Kesari S, Ashili S. Mesenchymal stem cells as living anti-inflammatory therapy for COVID-19 related acute respiratory distress syndrome. World J Stem Cells 2020; 12(10): 1067-1079
URL: https://www.wjgnet.com/1948-0210/full/v12/i10/1067.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i10.1067