HIF-2α regulates CD44 to promote cancer stem cell activation in triple-negative breast cancer via PI3K/AKT/mTOR signaling

Figure 7 Effect of HIF-2α on the PI3K/AKT signaling pathway. In MDA-MB-231 cells induced by hypoxia, HIF-2α knockdown reduced the AKT and mTOR phosphorylation levels; ^aP < 0.05 vs normoxia; ^bP < 0.05 vs hypoxia + NC. PI3K: Phosphoinosmde-3-kinase; AKT: Protein-serine-threonine kinase; mTOR: Mammalian target of rapamycin; p-AKT: Phosphorylated AKT; p-mTOR: Phosphorylated mTOR; NC: Negative-sequence control.