Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment: An experimental mouse model

Figure 5 Various stains validating effects of thioacetamide-induced secretome in the mouse model of thioacetamide-induced hepatic failure. A: TAA-induced conditioned media infusion significantly decreased both liver damage and kidney damage scores calculated based on hematoxylin and eosin staining; B: Immunohistochemical staining of liver specimens. Immunohistochemical stains showed that TAA-induced conditioned media infusion significantly decreased the expression of inflammatory markers (CD68 and PECAM) and significantly increased the expression of albumin. Values are presented as mean ± SD of three independent experiments. ^cP < 0.05 vs control (saline); ^eP < 0.05 between conditioned media and induced conditioned media. iCM: Induced secretome group of which components were the TAA-induced secretome; CM: Normal conditioned media group of which components were the naïve secretome; TAA: Thioacetamide.