Neural regeneration by regionally induced stem cells within post-stroke brains: Novel therapy perspectives for stroke patients

Figure 2 Prospects of regenerative therapy using injury/ischemia-induced neural stem/progenitor cells and injury/ischemia-induced multipotent stem cells. A: Strategic targeting of exogenously transplanted iNSPCs/iSCs. iNSPCs/iSCs exhibit high proliferative activity and differentiate into electrophysiologically-functional neurons in vitro. Thus, it is expected that transplanted iNSPCs/iSCs can differentiate into neuronal cells in vivo, thereby promoting central nervous system repair; B: A strategy for activating endogenous iNSPCs/iSCs. Administration of bioactive molecules has the potential to promote neural repair by regulating cell proliferation, cell differentiation, and cell death of endogenous iNSPCs/iSCs. iSCs: Injury/ischemia-induced multipotent stem cells; iNSPCs: Injury/ischemia-induced neural stem/progenitor cells.