Copyright
©The Author(s) 2019.
World J Stem Cells. Aug 26, 2019; 11(8): 476-490
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.476
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.476
Table 1 Possible molecules and their role in chronic myeloid leukemia stem cells-bone marrow microenvironment interaction
Target | Source | Role | Ref. |
G-CSF | CML LSC | Mobilization | [15] |
CD26 | CML LSC | Mobilization | [16] |
β1-integrins | CML LSC | Homing | [19] |
Selectins | CML LSC, endothelial cells | Homing | [20] |
CD44 | CML LSC | Homing | [20] |
Chemokines (MIP-1α, MIP-1β, etc) | BMM, CML LSC | Growth of CML LSC | [15,25] |
Cytokines (IL-1α, IL-1β, TNFα, etc) | BMM, CML LSC | Growth of CML LSC | [15,25] |
BMP2/4 | MSC, CML LSC | Drug resistance | [26] |
FGF2 | MSC | Drug resistance | [28] |
PIGF | MSC | Proliferation, metabolism | [29] |
miR-126 | CML LSC, endothelial cells | Dormancy | [30] |
HIF-1 | CML LSC | Growth of CML LSC | [15] |
Jagged-1 | Osteoblast | Dormancy | [94] |
Parathyroid hormone | BMM | CML LSC removal | [95] |
WNT | BMM | Growth of CML LSC | [21] |
N-cadherin | CML LSC | Drug resistance | [21] |
- Citation: Houshmand M, Blanco TM, Circosta P, Yazdi N, Kazemi A, Saglio G, Zarif MN. Bone marrow microenvironment: The guardian of leukemia stem cells. World J Stem Cells 2019; 11(8): 476-490
- URL: https://www.wjgnet.com/1948-0210/full/v11/i8/476.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v11.i8.476