Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues

doi:10.4252/wjsc.v11.i6.347

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Jun 26, 2019; 11(6): 347-374
Published online Jun 26, 2019. doi: 10.4252/wjsc.v11.i6.347

Table 2 Summary of biological properties of MSCs isolated from different tissues

Summary
Phenotype	Marker	BM-MSC			AT-MSC			SM-MSC			SK-MSC
	Marker	P1	P5	P10	P1	P5	P10	P1	P5	P10	P1	P5	P10
	CD73	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++
	CD90	+++	+++	+++	+++	+++	++	+++	+++	++	+++	+++	+++
	CD105	+++	++	++	+++	++	+	++	++	++	+++	+++	++
	CD146	+++	++	++	+++	+	+/-	+	+	+/-	+	+	++
	PDGFRα	++	++	+/-	+++	+	+/-	++	+	+	+	+	+
	PW1	-	+/-	+/-	++	+/-	+/-	+++	+/-	+/-	++	+/-	+/-
Differentiation	Tissue	BM-MSC			AT-MSC			SM-MSC			SK-MSC
	Tissue	P1	P5	P10	P1	P5	P10	P1	P5	P10	P1	P5	P10
	Osteo-	++	++	+++	+	++	+++	++	++	++	+	++	+++
	Adipo-	+++	++	+	+++	++	++	-	-	-	+	++	+/-
	Chondro-	++	++	+++	++	++	+++	+	++	++	+	++	++
mRNA ecpression	Gene	BM-MSC			AT-MSC			SM-MSC			SK-MSC
	Gene	P1	P5	P10	P1	P5	P10	P1	P5	P10	P1	P5	P10
	Sox2	+	++	+++	+	+	+	+	+	+	+++	+	+
	Oct4	+	++	+++	+	+	+	++	+/-	+	+	+	+
	p53	+	++	++	++	++	++	++	+	++	++	++	+
	c-myc	+	+++	++	+++	++	+++	++	++	++	++	++	++
Cytokines and chemokines	Cytokine	BM-MSC			AT-MSC			SM-MSC			SK-MSC
	Cytokine	P1	P5	P10	P1	P5	P10	P1	P5	P10	P1	P5	P10
	MCP-1	+	++	++	+/-	+	+	+	++	+	+	+	+
	IL-8	+	+++	+++	+/-	+	++	-	-	++	+	+	+
	VEGF	+++	+++	+	-	+	+/-	+	+	+/-	-	+/-	-
	IL-5	+/-	+/-	+/-	+/-	+/-	+/-	+/-	+/-	+/-	-	-	-
	IFN-γ	+/-	+	+/-	+/-	+/-	+	+/-	+	+/-	+/-	+/-	+/-
	IL-6	+/-	+	+	+++	+++	++	+/-	+	+	-	+/-	-
	MIP-1β	+	+	+	+	+	+	-	+/-	+	+/-	+/-	+/-

The gradation reflects the changes in the value of the examined parameters compared to passage 1: (-) negative, (+/-) weak, (+) moderate positive, (++) positive, (+++) strong positive.

Citation: Kozlowska U, Krawczenko A, Futoma K, Jurek T, Rorat M, Patrzalek D, Klimczak A. Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues. World J Stem Cells 2019; 11(6): 347-374
URL: https://www.wjgnet.com/1948-0210/full/v11/i6/347.htm
DOI: https://dx.doi.org/10.4252/wjsc.v11.i6.347