Review
Copyright ©The Author(s) 2019.
World J Stem Cells. Apr 26, 2019; 11(4): 222-235
Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.222
Table 3 Summary of intra-articular injection of expanded bone marrow-derived mesenchymal stem cells in knee osteoarthritis treatment (2015-2018)
Cell typeType of studyExperimental designCell dosageMeasurementResultsRef.
AutologousCase series (n = 61); Final follow up: 6 moPhase I/II studyNot mentionedVAS, WOMAC and X-raySignificantly reductions in knee pain and increased quality of life at 6 mo follow-upGaray-Mendoza et al[68], 2018
AutologousCase series (n = 13); Final follow up: 24 moPhase I/II studyIntra-articular injection of 30.5 × 106 MSCsMRI and KOOSAfter intra-articular injection with BM-MSCs had significantly improved the KOOS and knee cartilage thicknessAl-Najar et al[69], 2017
AllogeneicCase series (n = 60); Final follow up: 24 moDouble-blind, multicentric, placebo-controlled, phase II studyFour dose levels were studied in this trial: 25 × 106, 50 × 106, 75 × 106, and 150 × 106VAS, ICOAP and WOMACA 25 × 106 cell dose may be the most effective among the doses; WOMAC, ICOAP, and VAS scores decreased by the time of the final follow-up periodGupta et al[70], 2016
AutologousCase series (n = 30); Final follow up: 12 moDouble-blind, multicentric, phase I/II studyTwo dose levels were studied in this trial: 10 × 106 and 100 × 106VAS, WOMAC, X-ray and MRIA clinical and functional improvement of knee OA by the injection of 100 × 106 cell dose; Improvement of pain and knee function of OA patients at 12 mo follow-upLamo-Espinosa et al[71], 2016
AutologousCase series (n = 4); Final follow up: 60 moPhase I studyIntra-articular injection of 8-9 ×  106 MSCsWalking time, X-ray and VASEarlier transplantation may give better results in long-term follow-upSoler et al[72], 2016
AllogeneicCase series (n = 30); Final follow up: 12 moMulticentric, phase I/II studyIntra-articular injection of 40 × 106 MSCsVAS, WOMAC, and LEQUESNE; MRISignificantly improves cartilage quality and provides pain reliefVega et al[73], 2015
AutologousCase series (n = 30); Final follow up: 30 moNot mentionedIntra-articular injection of 0.5 × 106 MSCsWalking distance, VAS, WOMAC and MRISignificantly improves cartilage quality and knee function, and reduces pain levelEmadedin et al[74], 2015
AutologousCase series (n = 4); Final follow up: 60 moPhase I study,open labelIntra-articular injection of 8 × 106 MSCsVAS, Knee motion, Range, X-rayEarlier transplantation may give better results in long-term follow-upDavatch et al[75], 2016