Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review

doi:10.4252/wjsc.v11.i4.222

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2019; 11(4): 222-235
Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.222

Table 1 Summary of mesenchymal stem cell preclinical trials in osteoarthritis animal models from 2015 to 2018

Animal models (osteoarthritis)	MSC type	Interventions	Results	Ref.
Sheep	AD-MSCs	AD-MSCs/HA vs HA	µCT, MRI and immunohistochemistry: AD-MSCs/HA > HA	Lv et al[34], 2018
Sheep	Allogeneic AD-MSCs	AD-MSCs/HA vs HA	MRI and macroscopy examinations: AD-MSCs/HA > HA	Feng et al[35], 2017
Rabbits	BMSCs	BMSCs/HA vs PRP vs PRP/HA	Histological scores and immunohistochemistry: BMSCs/HA > PRP/HA > PRP	Desando et al[36], 2017
Rabbits	Allogeneic BMSCs	BMSCs/HA vs HA	Histological scores and cartilage content: BMSCs/HA > HA	Chiang et al[37], 2016
Dogs	AD-MSCs	AD-MSCs/PRP vs PRP	Focal compressive strength: AD-MSCs/PRP > PRP function and pain: AD-MSCs/PRP > PRP	Yun et al[38], 2016
Rabbits	AD-MSCs	AD-MSCs/PRP vs PRP	Macroscopic and histological examinations: AD-MSCs/PRP > PRP	Hermeto et al[39], 2016

OA: Osteoarthritis; AD-MSCs: Adipose-derived mesenchymal stem cells; HA: Hyaluronic acid; MRI: Magnetic resonance imaging; PRP: Platelet-rich plasma; BMSCs: Bone marrow-derived mesenchymal stem cells.

Citation: Wang AT, Feng Y, Jia HH, Zhao M, Yu H. Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review. World J Stem Cells 2019; 11(4): 222-235
URL: https://www.wjgnet.com/1948-0210/full/v11/i4/222.htm
DOI: https://dx.doi.org/10.4252/wjsc.v11.i4.222