Issues and opportunities of stem cell therapy in autoimmune diseases

Table 1 Indication of autologous hematopoietic stem cell transplantation in autoimmune diseases

Indication	Level of recommendation	Level of evidence
Systemic sclerosis	Clinical opportunity: a careful evaluation of the benefit / risk ratio is required	I
Multiple sclerosis		II
Chronic inflammatory demyelinating polyneuropathy		II
Myasthenia gravis		II
Crohn's disease		II
Systemic lupus erythematosus		II
Rheumatoid arthritis		II
Juvenile idiopathic arthritis		II
Autoimmune cytopenias		II
Polymyositis/dermatomyositis		III
Vasculitides		III
Neuromyelitis optica		III
Paraneoplastic neurological symptoms		III
Type 1 diabetes mellitus	Under construction	III
Refractory celiac disease		III