Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model

Figure 7 Evaluation of bioluminescent images, near-infrared fluorescence, and magnetic resonance imaging signals of labeled human bone marrow mesenchymal stem cells_Luc implanted in animals (sham groups). A: BLI image of the sham_control group after luciferin addition; B-D: BLI images after luciferin addition in the sham_S5, sham_S20 and sham_S50 groups; E: NIRF image of the sham_control group; F-H: NIRF images of the sham_S5, sham_S20 and sham_S50 groups; I, L: ex vivo NIRF images of all groups; M-Q: Sagittal and coronal MRI of the sham_control group; N-P: Sagittal MRI of the sham_s5, sham_s20 and sham_S50 groups, showing the position of iron signal detection with red arrows; R-T: Coronal MRI of the sham_s5, sham_s20 and sham_S50 groups, showing the position of iron signal detection with crossing green lines. (n = 7 rats/group). BLI: Bioluminescent images; hBM-MSC: Human bone marrow mesenchymal stem cells; NIRF: Near-infrared fluorescence; MRI: Magnetic resonance imaging.