Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits

Figure 4 Concentration of pro-inflammatory cytokines in the synovial fluid 1 wk (white), 2 wk (light grey), 4 wk (dark gray), and 8 wk (black) after cell transplantation. A: Sham control; B: ACLT alone; C: Low-dose (1.7 × 10⁶) hADMSCs; D: High-dose (1.7 × 10⁷) hADMSCs; E: Low-dose (1.7 × 10⁶) hADMSCs + TSP2 (100 ng); F: TSP2. ^aSignificantly different from sham control, P < 0.05. ^bSignificantly different from ACLT alone, P < 0.05. hADMSCs: Human adipose-derived mesenchymal stem cells; TSP2: Thrombospondin 2.