Copyright
©The Author(s) 2019.
World J Stem Cells. Dec 26, 2019; 11(12): 1104-1114
Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1104
Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1104
Figure 3 Biomechanical stress stimulates the mechanosensitive molecules on the EPC surface, and then induces cytoskeleton rearrangement and activates series of downstream signaling pathway.
The following cascades lead to change of gene expression, ultimately influencing the cell fundamental activities including cell proliferation, differentiation, recruitment, and motivation, depending upon the need of vessel repair. EPCs: Endothelial progenitor cells; ECs: Endothelial cells; SMCs: Smooth muscle cells. The black arrow points out the direction of stress.
- Citation: Tian GE, Zhou JT, Liu XJ, Huang YC. Mechanoresponse of stem cells for vascular repair. World J Stem Cells 2019; 11(12): 1104-1114
- URL: https://www.wjgnet.com/1948-0210/full/v11/i12/1104.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v11.i12.1104