Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits

Table 2 Gross evaluation scores

Treatment (dose)	Roughness of surface	Adhesion with meniscus	Hypertrophy of joint	Osteophyte	Total score
	(0-8)	(0-8)	(0-8)	(0-8)	(0-32)
ACLT alone	5.5 ± 0.5	4.5 ± 0.5	6.0 ± 0.4	4.0 ± 2.0	20.0 ± 3.1
hADMSCs (low)	4.0 ± 1.0	4.0 ± 1.0	5.0 ± 1.0	4.0 ± 1.2	17.0 ± 2.2
hADMSCs (high)	2.0 ± 1.1	2.5 ± 0.5	2.5 ± 1.5	1.5 ± 0.5	8.5 ± 2.51
hADMSCs (low) + TSP2	3.0 ± 0.2	1.5 ± 0.6	1.0 ± 0.4	2.0 ± 0.6	7.5 ± 0.51
TSP2 (100 ng)	1.5 ± 1.5	3.5 ± 0.5	3.5 ± 1.5	3.0 ± 1.1	11.5 ± 4.51

¹Significantly different from ACLT alone, P < 0.05. ACLT: Anterior cruciate ligament transection; hADMSCs: Human adipose-derived mesenchymal stem cells; TSP2: Thrombospondin 2.