Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits

Table 1 Radiological evaluation scores 8 wk after cell transplantation

Treatment (dose)	Osteophytes in medial femoral condyle (0-5)	Deformity of medial tibia (0-5)	Sharpening of tibial spine (0-5)	Total score (0-15)
ACLT alone	3.5 ± 0.2	3.2 ± 0.4	2.7 ± 0.3	9.3 ± 0.6
hADMSCs (low)	3.0 ± 0.4	3.0 ± 0.4	2.7 ± 0.2	8.7 ± 0.4
hADMSCs (high)	2.7 ± 0.2	2.3 ± 0.2	2.2 ± 0.2	7.2 ± 0.31
hADMSCs (low) + TSP2	2.3 ± 0.3	1.5 ± 0.3	2.5 ± 0.3	6.0 ± 0.41
TSP2 (100 ng)	2.5 ± 0.3	2.5 ± 0.3	2.3 ± 0.3	7.2 ± 0.81

¹Significantly different from ACLT alone, P < 0.05. ACLT: Anterior cruciate ligament transection; hADMSCs: Human adipose-derived mesenchymal stem cells; TSP2: Thrombospondin 2.