Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells

Figure 5 Effects of MCM on the expression of antioxidant enzymes in the liver. Upon comparing immunohistochemical staining patterns, MCM infusion was observed to lead to a higher expression of SOD, catalase, and GPx in the livers of thioacetamide (TAA)-treated mice. The graphs below microscopic figures show the relative densities of these markers. Percentages of immunoreactive areas were measured using NIH image J and expressed as relative values to those in normal livers. Magnification × 400. Values are presented as mean ± standard deviation of three independent experiments. ^aP < 0.05 vs Ct (TAA). ^cP < 0.05 between TAA + NCM and TAA + MCM. Ct: Control; CM: The secretome obtained from ASCs after 48-h-incubation; GPx: Slutathione peroxidase; MCM: The secretome released from miR-122-transfected ASCs; SOD: Superoxide dismutase; TAA: Thioacetamide.