Monitoring maturation of neural stem cell grafts within a host microenvironment

Figure 1 Schematic illustration for neurogenesis of neural stem cell (NSC) grafts within a host hippocampal tissue, showing the difference in relative proportions for neuronal (yellow) vs glial (purple) NSC lineage between physiological environment (a) and the post-ischemic milieu (tissue subjected to oxygen-glucose deprivation) (b) at an earlier time-window – first 2 weeks after engraftment into organotypic hippocampal tissue. NSC are fetal progenitors isolated from mouse hippocampus grafted into organotypic hippocampal slices for monitoring the time-dependent NSC neurogenesis within a host tissue.