Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies

doi:10.4252/wjsc.v11.i11.920

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2019; 11(11): 920-936
Published online Nov 26, 2019. doi: 10.4252/wjsc.v11.i11.920

Table 6 Negative correlation between combined expression of cancer stem cell markers CD133, CD44 and CD166 and epigenetic readers

Family/gene symbol	Putative epidrug/chemical probe	Z-score	P value
Methylated DNA binding
MBD3	-	-3.601	0.0003174
ZBTB38 (Kaiso family)	-	-2.557	0.01055
Histone binders
Bromodomains
BRD7	BI7273³, BI-9564³, TP-472³[97]	-4.906	9.301E-07
Zinc finger, Plant Homeodomain (PHD)-type
ING1, ING5	-	-2.544/-4.255	< 0.05
PHF20	-	-3.094	0.001973
PHF14	-	-2.934	0.003344
PHF5A	-	-2.521	0.01171
DPF1	-	-2.78	0.00543
Tudor domain
TDRKH	-	-2.755	0.005875
WD40 motif
EED	A-395³[98]	-4.307	1.652E-05
Other cofactors of epigenetic complexes
DPY30	-	-3.549	0.0003863
WDR5	OICR-9429³	-3.31	0.0009321
TADA2A		-2.473	0.01341

¹Approved for the treatment of other diseases; ²Used in clinical trials for other diseases;

³Not yet used in clinical trials.

Citation: Vincent A, Ouelkdite-Oumouchal A, Souidi M, Leclerc J, Neve B, Van Seuningen I. Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies. World J Stem Cells 2019; 11(11): 920-936
URL: https://www.wjgnet.com/1948-0210/full/v11/i11/920.htm
DOI: https://dx.doi.org/10.4252/wjsc.v11.i11.920