Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies

doi:10.4252/wjsc.v11.i11.920

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2019; 11(11): 920-936
Published online Nov 26, 2019. doi: 10.4252/wjsc.v11.i11.920

Table 5 Positive correlation between combined expression of cancer stem cell markers CD133, CD44 and CD166 and epigenetic readers

Family/gene symbol	Epidrug/chemical probe	Z-score	P value
Methylated DNA binding
MBD1	-	2.593	0.009517
MBD2	-	3.477	0.0005076
ZBTB4	-	5.496	3.89E-08
Methylated histone binders
Zinc finger, PHD-type
DPF3		3.503	0.0004602
Bromodomain	Apabetalone², Bromosporine³
BPTF		2.621	0.008773
BAZ2B	GSK2801³	4.791	1.66E-06
Tudor domain
TDRD1	-	2.459	0.01394
TP53BP1	-	2.965	0.003029
Other cofactors of epigenetic complexes
RBBP5	-	2.966	0.003014
TADA2B	-	3.382	0.0007189
ELP2	PLX-4720³	3.277	0.00105
ELP3	-	2.622	0.00875
TAB2	-	2.551	0.01074
NCOR1	-	3.62	0.0002949
Chromodomain (Chromatin Organization Modifier Domain)
CHD1, CHD3, CHD9	-	3.007/4.099/4.367	< 0.003

¹Approved for the treatment of other diseases;

²Used in clinical trials for other diseases;

³Not yet used in clinical trials.

Citation: Vincent A, Ouelkdite-Oumouchal A, Souidi M, Leclerc J, Neve B, Van Seuningen I. Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies. World J Stem Cells 2019; 11(11): 920-936
URL: https://www.wjgnet.com/1948-0210/full/v11/i11/920.htm
DOI: https://dx.doi.org/10.4252/wjsc.v11.i11.920