Copyright
©The Author(s) 2018.
World J Stem Cells. Sep 26, 2018; 10(9): 119-133
Published online Sep 26, 2018. doi: 10.4252/wjsc.v10.i9.119
Published online Sep 26, 2018. doi: 10.4252/wjsc.v10.i9.119
Figure 2 Sphingosine kinase/sphingosine-1-phosphate signaling axis in neural stem/progenitor cells (hypothetical scheme).
Activation of S1P3 receptor signaling and activation of neural cell progenitor differentiation are mediated by various downstream effectors including PKC, PI3K/Akt, MAPK/Erk1/2, NT3, and CREB/NF-κB TFs. SphK: Sphingosine kinase; S1P: Sphingosine-1-phosphate; CREB: cAMP-response element binding protein; NT3: Neurotrophin 3; TF: Transcription factor.
- Citation: Ng ML, Yarla NS, Menschikowski M, Sukocheva OA. Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells. World J Stem Cells 2018; 10(9): 119-133
- URL: https://www.wjgnet.com/1948-0210/full/v10/i9/119.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v10.i9.119