Cancer stem cell impact on clinical oncology

Table 1 Cancer stem cells markers in solid tumors

Cancer type	Phenotype	Model	References
Prostate cancer	CD44+	PCa cell line and tumor xenograft in mice	[58]
Breast cancer	CD44+ CD24-/low	Patient-derived tumor xenograft in mice	[5]
Cervical cancer	CD44+ CD24+	SiHa cell line	[55]
Gastric cancer	CD44+ CD24+	AGS cell line and patient tissue samples	[56]
Nasopharyngeal carcinoma	CD24-	NPC cell lnes, mice	[54]
Gastric adenocarcinoma	CD44+ CD133+	Patient tissue samples	[51]
Oral squamous cell carcinoma	CD44+ ALDH1	Metastatic lymph nodes	[153]
Breast cancer	CD44v	Clinical samples	[154]
Prostate cancer	CD133	Primary prostate cancer cell lines	[155]
Endometrial cancer	CD133	Human endometrial cell lines	[42]
Liver cancer	CD133	Huh-7 cells and tumor xenograft in mice	[47]
Prostate cancer	CD133	Primary human prostate cancer cell lines	[155]
Cervical cancer	CD49f	SiHa and HeLa cell lines	[156]
Non-small cell lung cancer	CD49f	Patient-derived sphere-forming assays	[157]
Gastric cancer	CD49f	Gastric tumor tissues and tumor xenograft in mice	[75]
Colon cancer	CD49f	HT29 and Caco2 cell lines, clinical samples	[77]
Cervical cancer	ALDH	SiHa and HeLa cell lines, mice model	[85]
Colon cancer	ALDH1A3	HT29 cell line	[158]
Colon cancer	ALDH1A1	HT29 cell line and tumor xenograft in mice	[159]
Breast cancer	ALDH	Breast cancer tumor tissues	[160]

CSCs: Cancer stem cells; ALDH: Aldehyde dehydrogenase; NPC: Nasopharyngeal carcinoma.