Pancreatic cancer stem cells: Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma

doi:10.4252/wjsc.v10.i11.172

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2018; 10(11): 172-182
Published online Nov 26, 2018. doi: 10.4252/wjsc.v10.i11.172

Table 2 Deregulated pathways and proteins to target pancreatic cancer stem cells

Deregulated pathways	Compound or strategy	Ref.
Hedgehog	Crocetinic acid	[55]
	Sanguinarine	[56]
	GANT61	[57]
Notch	RO4929097, shRNA	[58]
Notch	Quinomycin A	[59,97,98]
mTOR	Rapamycin	[60]
mTOR	AZD8055	[61]
Deregulated proteins	Compound or strategy
FASN	Cerulenin	[7]
AnxA1	siRNA	[64]
MARCKS	MANS peptide	[66]
Galectin-3	Polysaccharide RN1	[70]
PKM2	Lapachol	[72]
PKM2	Diallyl disulphide	[73]
ERRγ	GSK5182	[82,83]

shRNA: Short hairpin RNA; siRNA: Small interfering RNA; FASN: Fatty acid synthase; mTOR: Mammalian target of rapamycin; AnxA1: Annexin A1; MARCKS: Myristoylated alanine-rich C-kinase substrate; PKM2: Pyruvate kinase isozyme M2.

Citation: Di Carlo C, Brandi J, Cecconi D. Pancreatic cancer stem cells: Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma. World J Stem Cells 2018; 10(11): 172-182
URL: https://www.wjgnet.com/1948-0210/full/v10/i11/172.htm
DOI: https://dx.doi.org/10.4252/wjsc.v10.i11.172