Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease

Table 2 Relationship between angiogenesis protein secreted by adipose-derived mesenchymal stem cells and liver cirrhosis

UniProt/SWISS-
PROT ID	Description		Reference
PAI1	Plasminogen activator inhibitor 1	PAI-1 regulates angiogenesis via effects on extracellular matrix proteolysis and cell adhesion	[87]
FSTL1	Follistatin-related protein 1	Knockdown of Fstl1 attenuates hepatic stellate cell activation through the TGFβ1/Smad3 signaling pathway	[88]
POSTN	Periostin	POSTN, a ligand of αvβ3/5 integrins, as an effector protein in SULF2-induced angiogenesis	[89]
MMP2	72 kDa type IV collagenase	MMP2 has an important role in the preservation of liver vascular homeostasis	[91]
TSP1	Thrombospondin-1	TSP1 was reported to be increased in HSCs isolated from the liver of CCl4-induced cirrhosis model mice	[92]
TIMP1	Metalloproteinase inhibitor 1	Inhibition of TIMP1 was reported to promote angiogenesis by increasing cell motility during fibrovascular invasion	[93]
FBLN3	EGF-containing fibulin-like extracellular matrix protein 1	FBLN3 has been reported as an angiogenesis antagonist regulating cell morphology, growth, adhesion and motility	[95]
MFGM	Lactadherin	MFGM promote angiogenesis via enhanced PDGF-PDGFRβ signaling mediated by cross-talk of the integrin growth factor receptor	[97]