Efficacy and safety of autologous stem cell transplantation for decompensated liver cirrhosis: A retrospective cohort study

Table 1 Comparison of the baseline demographic and clinical characteristics between the stem cell transplantation group and the non-transplantation group

Characteristic	Before propensity score matching			After propensity score matching
	Stem cell transplantation group (n = 27)	Non-transplantation group (n = 132)	P-value	Stem cell transplantation group (n =23)	Non-transplantation group (n = 69)	P-value
No. of male (%)	18 (66.7%)	100 (75.8%)	0.325	15 (65.2%)	45 (65.2%)	1
Age (yr)	53.7 ± 9.7	53.3 ± 10.8	0.84	53.0 ± 9.7	55.3 ± 9.8	0.351
History of smoking (%)	6 (22.2)	33 (25.0)	0.76	4 (17.4)	15 (21.7)	0.656
History of alcohol drinking, n (%)	8 (29.6)	33 (25.0)	0.616	6 (26.1)	20 (29)	0.789
Diabetes, n (%)	6 (22.2)	23 (17.4)	0.556	6 (26.1)	16 (23.2)	0.778
Family history of liver cancer, n (%)	3 (11.1)	10 (7.6)	0.541	3 (13)	3 (4.3)	0.144
Child-Pugh B to C ratio	4:23	67:65	0.001	4:19	17:52	0.473
MELD score	14.36 (9.33-18.69)	10.43 (7.22-15.91)	0.051	15.55 ± 7.66	14.21 ± 8.32	0.498
HBsAg positive, n (%)	20 (74.1)	127 (96.2)	0	20 (87)	66 (95.7)	0.144
PT (s)	21.5 (18.2-26.7)	18.2 (16.0-20.7)	0.003	22.0 (18.1-27.8)	19.3 (16.8-22.6)	0.143
TBIL (µmol/L)	88.7 (46.6-141.1)	38.4 (23.1-111.6)	0.012	73.2 (46.6-137.9)	46.4 (26.6-155.6)	0.21
ALB (g/L)	26.89 ± 4.36	28.16 ± 5.63	0.268	27.08 ± 4.59	26.27 ± 6.02	0.56
ALT (U/L)	45 (30-60)	54 (35-113)	0.055	47 (36-63)	48 (30-93)	0.701
PLT (× 109/L)	79.11 ± 40.39	92.66 ± 58.39	0.252	81.78 ± 41.33	90.49 ± 65.35	0.551
AFP (ng/mL)	7.62 (3.68-20.80)	6.90(2.73-33.87)	0.889	7.93 (3.9-29.37)	6.3 (2.47-23.88)	0.564
HBeAg titer (s/copies)	0.45 (0.34-11.26)	0.5 (0.34-24.68)	0.808	0.45 (0.34-11.26)	0.48 (0.34-22.13)	0.906
LogHBV DNA (IU/mL)	4.45 ± 1.21	4.47 ± 1.44	0.966	4.45 ± 1.21	4.65 ± 1.48	0.097
Cause, n (%)
HBV infection	20 (74.1)	127 (96.2)	0	20 (87)	66 (95.7)	0.154
Alcohol drinking	4 (14.8)	1 (0.8)		1 (4.3)	0
Others	3 (11.1)	4 (3)		2 (8.7)	3 (4.3)

MELD: Model for end-stage liver disease; HBsAg: Hepatitis B surface antigen; PT: Prothrombin time; TBIL: Total bilirubin; ALB: Albumin; ALT: Alanine aminotransferase; PLT: Platelet; AFP: Alpha fetoprotein; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus.