CircRASSF2靶向miR-218-5p调控胃癌细胞增殖、迁移和凋亡的研究

表6 circRASSF2和miR-218-5p影响细胞抑制率和克隆形成(mean±SD, n = 9)

分组		抑制率/%	克隆形成数/个	凋亡率/%	迁移细胞数/个
HGC-27	si-NC	0.00±0.00	112.52±6.25	8.07±0.47	169.89±10.80
	si-circRASSF2	55.23±2.34a	40.27±3.36a	22.89±1.15a	73.00±2.54a
	miR-NC	0.03±0.03	101.40±9.33	8.11±0.57	171.00±11.17
	miR-218-5p mimic	44.19±2.70b	42.26±4.11b	19.78±1.13b	85.78±3.91b
	si-circRASSF2+anti-miR-NC	55.01±2.75	37.21±3.38	23.06±1.36	69.56±3.47
	si-circRASSF2+miR-218-5p Inhibitor	20.36±1.22c	89.27±8.25c	13.31±0.79c	146.44±7.26c
AGS	si-NC	0.00±0.00	55.26±6.42	5.64±0.67	116.51±12.14
	si-circRASSF2	43.84±5.77a	24.33±2.27a	18.96±1.52a	56.58±6.36a
	miR-NC	0.01±0.02	46.28±4.18	4.98±0.58	113.84±12.21
	miR-218-5p mimic	45.26±5.10b	18.22±2.14b	19.27±2.21b	52.27±5.95b
	si-circRASSF2+anti-miR-NC	44.1±4.5	19.33±1.74	19.04±2.02	57.43±6.27
	si-circRASSF2+miR-218-5p Inhibitor	18.62±1.92c	40.39±3.85c	9.25±0.97c	101.22±10.61c
F		1569.442	375.574	429.625	379.610
P		<0.05	<0.05	<0.05	<0.05

^aP<0.05 vs si-NC组;

^bP<0.05 vs miR-NC组;

^cP<0.05 vs si-circRASSF2+anti-miR-NC组. si-NC: 小干扰RNA阴性对照; si-circRASSF2: circRASSF2的小干扰RNA; miR-NC: miRNA阴性对照; miR-218-5p mimic: miR-218-5p模拟物; anti-miR-NC: miRNA抑制剂阴性对照; miR-218-5p inhibitor: miR-218-5p抑制剂.