中国不同地区幽门螺杆菌耐药状况的荟萃分析

表1 纳入文献的基本特征

作者	地区	时间	样本量	CLA	LEV	AMX	TET	MNZ	FZD	CLA+MNZ	LEV+MNZ	CLA+LEV	CLA+LEV+MNZ	LEV+MNZ+AMX	CLA+MNZ+AMX
Gong等[14]	北京	2013-2019	138					70.29%
	黑龙江		25					84.00%
	山东		76					73.68%
	湖南		38					92.11%
	广西		76					72.37%
	云南		57					78.95%
	贵州		10					50.00%
	青海		22					86.36%
	宁夏		64					78.13%
Pan等[15]	上海	1995	81	4.94%
	广东		15	6.67%
Gao等[16]	北京	2000	54	14.81%		1.85%		38.89%
		2001	71	16.90%		0		36.62%
		2002-2003	27	22.22%		0		59.26%
		2004-2005	27	29.63%		0		74.07%
		2006-2007	80	43.75%	27.08%	0	2.04%	81.25%
		2008	63	57.14%	57.14%	0	0	79.37%
		2009	52	65.38%	63.46%	0	1.92%	78.85%
Wang等[17]	北京	2007-2009	79		55.7%
Ru等[18]	北京	2012	70	15.71%	12.86%	1.43%		61.43%
		2013	74	16.22%	21.62%	1.35%		59.46%
		2014	82	20.73%	18.29%	0		79.27%
		2015	77	22.08%	20.78%	1.30%		68.83%
		2016	83	22.89%	20.48%	3.61%		85.54%
		2017	72	23.61%	23.61%	4.17%		91.67%
		2018	81	24.69%	22.22%	4.94%		88.89%
Bai等[19]	北京	2013	181	30.93%		3.87%		61.33%		26.52%
Li等[20]	北京	2013-2020	365	85.75%	68.77%	2.19%	0	77.53%		16.71%
Tian等[21]	北京	2014-2015、2018-2019	160	25.63%	67.50%	15.00%	0	96.25%		7.5%	40.00%		18.13%	9.38%
Lok等[22]	北京	2018-2019	65	52.31%	38.46%							26.15%
Gao等[23]	北京	2022发表	364	65.06%		7.54%	20.37%
原素梅等[24]	山西	2011-2012	243	7.41%	12.35%	7.41%		75.31%	8.64%
Wang等[25]	辽宁	1998-1999	23	39.1%	47.8%	4.3%	13.0%	87.0%
		2002-2004	50	14.0%	46.0%	2.0%	14.0%	66.0%
		2016-2017	27	55.6%	81.5%	25.9%	18.5%	92.6%
Hao等[26]	辽宁	2004发表	30	23.33%		0	6.67%	40.00%
郎轶萱等[27]	吉林	2010-2011	213	17.84%	30.05%	2.82%		52.11%
Wu等[28]	上海	1998-1999	153			71.90%	58.82%	77.78%
Sun等[29]	上海	2000	58	8.62%	10.34%	0	0	48.28%	0
		2005	100	9.00%	24.00%	0	1.00%	49.00%	0
		2009	135	20.74%	32.59%	0	0	42.22%	0
Zheng等[30]	上海	2008-2009	77	20.78%		0	0	41.56%		11.69%
Wang等[31]	上海	2019-2020	1116	27.78%	31.09%	0.09%	0.09%	79.93%	0.54%	11.56%	15.14%	1.16%	12.01%
Liu等[32]	上海	2022发表	112	16.07%	34.82%	0		65.18%
Su等[33]	江苏	2006发表	46						8.70%
Jiang等[34]	江苏	2017-2019	1533	47.03%	33.59%	2.74%	0.52%	80.76%	0.91%
Zhang等[35]	江苏	2018-2019	461	41.00%	44.90%	6.30%	1.10%	38.82%		5.86%	9.76%	14.32%	6.72%	0.22%	0.22%
Jiang等[36]	江苏	2018-2021	2772	46.10%	32.47%	0.90%	0.07%	69.70%	0.29%	14.54%	6.17%	3.32%	20.42%	0.04%	0.29%
Su等[37]	江苏	2010-2012	34	20.6%	29.4%			94.1%
	浙江		17697	21.5%	20.6%			95.3%
Ji等[38]	浙江	2009	381	14.17%	10.50%	0		100%	0.03%	14.17%	10.50%	0.52%	0.52%
		2010	360	25.00%	16.94%	0		95.56%	0	22.78%	15.56%	6.39%	5.56%
		2011	608	26.15%	25.66%	0		93.09%	0	23.85%	25.66%	11.84%	10.36%
		2012	1108	19.86%	21.84%	0		96.48%	0	18.77%	21.48%	7.40%	7.22%
		2013	3412	15.36%	17.26%	0		94.26%	0	15.36%	15.74%	6.80%	6.01%
		2014	3818	17.63%	21.37%	0.03%		96.25%	0	16.63%	20.40%	7.18%	6.84%
Zhang等[39]	浙江	2011-2020	94509	23.99%	30.29%	0.21%		93.72%		11.16%	17.37%	0.47%	11.63%	0.05%	0.03%
Shao等[40]	浙江	2013-2016	2283	22.73%	24.75%	1.58%			1.49%			10.16%
Pan等[41]	浙江	2014	467	26.12%	28.69%	0		96.79%	0
Dai等[42]	浙江	2017-2020	111	32.43%	35.14%	0	0	90.09%	0	30.63%	33.33%		20.72%
Wang等[43]	江西	2018-2019	124	35.48%	40.32%			79.84%
Yakoob等[44]	湖南	1996-1999	50	8.00%			0	50.00%		6.00%
Hu等[45]	湖南	2023发表	104	38.50%	27.88%	13.46%	0	61.54%	0	27.88%	20.19%	15.38%	13.46%	3.85%	6.73%
孙剑刚等[46]	湖北	2009-2010	156	12.18%		14.10%	0	65.38%	7.05%
王松等[47]	湖北	2017-2019	460	21.74%		13.04%	39.13%	43.48%
Li等[48]	广东	2020	54	50.00%	33.33%	18.52%	12.96%	77.78%		11.11%	7.41%	1.85%	14.81%
Han等[49]	广东	2021-2022	88	26.14%	31.82%							11.36%
Huang等[50]	广东、福建	2017-2020	208	38.94%	35.10%	57.21%	12.98%	39.42%	11.05%
Zhao等[51]	广西	2011-2012	115	31.30%
Tang等[52]	西藏	2018-2020	153	27.45%	31.37%	15.69%	0	86.27%	0.65%				2.61%		0.65%
Yang等[53]	云南	2023发表	276	33.70%	78.99%	11.59%	40.94%	80.43%
吴芳草等[54]	贵州	2016-2018	351	33.05%	38.46%	13.96%	17.09%	68.38%		5.41%	11.97%	2.28%	5.41%	0.57%	1.42%
周钢等[55]	重庆	2009	100		4.00%
		2013	100		12.00%
Xu等[56]	甘肃	2018-2020	198	55.05%	46.46%	16.16%	7.58%	85.86%		15.66%	12.63%	1.01%	18.69%	0.51%	2.02%
Yun等[57]	甘肃	2020-2021	112	41.96%	35.71%	15.18%	5.36%	83.04%		11.61%	10.71%		15.18%	1.79%	2.68%
Hu等[58]	宁夏	2020-2022	1955	40.41%	42.40%	0.87%	0.26%	94.17%	0.05%	16.21%	18.31%	0.82%	21.69%	0.20%	0.10%
顾勇等[59]	陕西	2016-2017	119	10.08%	14.29%	1.68%		28.57%		5.88%	4.20%

CLA: 克拉霉素; LEV: 左氧氟沙星; AMX: 阿莫西林; TET: 四环素; MNZ: 甲硝唑; FZD: 呋喃唑酮.