解整合素-金属蛋白酶33基因多态性与胆管癌及血清肿瘤标志物水平的相关性研究

表3 ADAM33 rs678881、rs2853209各基因型胆管癌患者患儿的CA19-9、sICAM-1及CEA水平比较(mean±SD)

基因型	n	CA19-9(ng/mL)	sICAM-1(IU/mL)	CEA(μg/L)
rs678881
GG	86	121.73±75.28	912.69±193.72	5.62±3.14
GC	78	167.26±83.36a	1024.25±209.36a	6.79±4.68a
CC	48	180.62±92.44ab	1205.63±227.31ab	9.81±5.42ab
F		10.040	30.743	14.627
P		0.000	0.000	0.000
rs2853209
AA	78	151.72±50.88	911.27±112.41	5.37±3.08
AT	75	153.21±68.37	938.69±131.79	5.93±4.46
TT	59	159.60±57.39	959.21±127.35	5.82±4.77
F		0.289	2.502	0.432
P		0.750	0.084	0.650

^aP<0.05, 与GG相比;

^bP<0.05, 与GC相比. sICAM-1: 可溶性细胞间分子-1; CEA: 癌胚抗原; CA19-9: 癌细胞表面抗原.