CEA、CA 19-9和CA242联合检测能否提高结直肠癌诊断的敏感性和诊断价值: Meta分析

表1 单个肿瘤标志物检测特征

纳入研究	年份	CEA			CA19-9			CA242
		检测方法	临界值(ng/mL)	tp/fp/fn/tn	检测方法	临界值(U/mL)	tp/fp/fn/tn	检测方法	临界值(U/mL)	tp/fp/fn/tn
陈文彰等[19]	2007	RIA	15	32/1/30/29	RIA	37	27/0/35/30	RIA	25	32/0/30/30
程金玲[20]	2014	CLIA	5	29/17/31/66	CLIA	37	21/15/39/68	CLIA	20	24/12/36/71
Dong等[21]	2018	ECLI	5	76/10/32/46	ECLI	37	47/4/61/52	ECLI	20	29/3/79/53
何乐等[22]	2016	Protein chip	5	71/2/79/168	Protein chip	35	28/4/122/166	Protein chip	20	36/1/114/169
胡红永等[23]	2010	CLIA	8	41/2/48/48	CLIA	35	40/3/49/47	RIA	25	50/1/39/49
江波等[24]	2006	ELISA	2.4	80/7/70/193	ELISA	27.4	49/15/101/185	ELISA	11	87/22/63/178
荆卫娟等[25]	2015	CLIA	5	45/23/38/67	CLIA	37	34/4/49/86	CLIA	20	33/2/50/88
龙驰等[26]	2012	Protein chip	5	53/6/77/102	Protein chip	35	36/10/94/98	Protein chip	20	40/4/90/104
彭莉等[27]	2006	ECLI	3.4	58/2/34/34	ECLI	37	45/5/47/31	ECLI	20	54/4/38/32
王兵济等[28]	2010	Protein chip	5	79/5/121/95	Protein chip	35	46/4/154/96	Protein chip	20	38/2/162/98
王科学[29]	2016	CLIA	5	67/12/61/174	CLIA	37	60/15/68/171	CLIA	25	72/10/56/176
王堃等[30]	2017	CLIA	7.2	46/4/55/100	CLIA	27	41/4/60/100	CLIA	20	31/3/70/101
张辉等[31]	2017	ECLI	5	37/9/49/77	ECLI	37	23/7/63/79	ECLI	20	21/8/65/78
章万忠等[32]	2007	RIA	5	23/2/7/28	RIA	37	16/0/14/30	RIA	20	23/1/7/29
钟志等[33]	2014	Protein chip	5	26/2/34/28	Protein chip	35	19/3/41/37	Protein chip	20	17/2/43/38
仲召阳等[13]	2007	Protein chip	5	99/8/140/71	Protein chip	35	64/5/175/74	Protein chip	20	61/5/178/74
朱美芹[34]	2016	CLIA	5.093	33/13/28/104	CLIA	37	28/10/33/107	CLIA	15	22/10/39/107
邹超世等[35]	2018	CLIA	5	50/1/52/37	CLIA	27	62/5/40/33	CLIA	25	73/4/29/34

CLIA: 化学发光免疫分析法; ECLI: 电化学发光免疫分析法; ELISA: 酶联免疫法; RIA: 放射免疫法. tp: 真阳性; fp: 假阳性; fn: 真阴性; tn: 假阴性.