基于HOXB8基因的结直肠癌预后模型及列线图的建立与验证

表3 结直肠癌患者的总生存期与无进展生存期的多因素COX分析

	OS		PFS
	HR (95%CI)	P值	HR (95%CI)	P值
年龄	2.508 (1.628-3.864)	<0.001	-	-
HOXB8表达水平	0.974 (0.655-1.446)	0.894	1.539 (1.066-2.221)	0.021
AJCC T stage		0.009		0.016
T1	Reference		Reference
T2	0.561 (0.117-2.692)	0.47	0.845 (0.182-3.922)	0.829
T3	0.784 (0.186-3.312)	0.741	1.694 (0.410-6.987)	0.466
T4	1.766 (0.393-7.931)	0.458	2.906 (0.664-12.714)	0.156
AJCC N stage		0.002		0.004
N0	Reference		Reference
N1	1.382 (0.818-2.335)	0.227	1.055 (0.662-1.681)	0.82
N2	2.508 (1.492-4.216)	0.001	2.054 (1.275-3.307)	0.003
AJCC M stage		0.005		<0.001
M0	Reference		Reference
M1	2.289 (1.382-3.789)	0.001	2.986 (1.888-4.721)	<0.001
Mx	1.619 (0.855-3.066)	0.139	1.220 (0.658-2.259)	0.527

OS: 总生存期; PFS: 无进展生存期.