基于HOXB8基因的结直肠癌预后模型及列线图的建立与验证

表2 结直肠癌患者的总生存期与无进展生存期的单因素COX分析

	OS		PFS
	HR (95%CI)	P值	HR (95%CI)	P值
性别	1.016 (0.699-1.478)	0.932	1.172 ( 0.828-1.656)	0.37
年龄	2.214 (1.449-3.381)	<0.001	1.068 (0.754-1.512)	0.711
肿瘤位置		0.157		0.98
左半	Ref.		Ref.
右半	1.487 (0.986-2.241)	0.058	1.033 (0.709-1.506)	0.862
未知	1.147 (0.646-2.033)	0.639	0.994 (0.607-1.626)	0.981
放射治疗	1.340 (0.919-1.953)	0.128	0.909 (0.644-1.283)	0.59
HOXB8表达水平	1.148 (0.788-1.673)	0.472	1.742 (1.222-2.482)	0.002
AJCC T stage		<0.001		<0.001
T1	Ref.		Ref.
T2	0.924 (0.195-4.367)	0.92	0.864 (0.186-4.008)	0.852
T3	1.769 (0.434-7.211)	0.425	2.342 (0.576-9.512)	0.233
T4	5.622 (1.326-23.842)	0.019	6.738 (1.600-28.380)	0.009
AJCC N stage		<0.001		<0.001
N0	Ref.		Ref.
N1	1.717 (1.070-2.757)	0.025	1.680 (1.099-2.569)	0.016
N2	4.005 (2.593-6.185)	<0.001	4.082 (2.716-6.135)	<0.001
AJCC M stage		<0.001		<0.001
M0	Ref.		Ref.
M1	3.904 (2.569-5.932)	<0.001	4.681 (3.187-6.875)	<0.001
Mx	1.716 (0.921-3.197)	0.088	1.207 (0.656-2.217)	0.545
AJCC stage		<0.001		<0.001
Ⅰ	Ref.		Ref.
Ⅱ	1.883 (0.784-4.519)	0.156	2.241 (1.051-4.776)	0.036
Ⅲ	3.450 (1.455-8.180)	0.004	3.370 (1.577-7.203)	0.001
Ⅳ	8.064 (3.390-19.183)	<0.001	10.66 (4.990-22.779)	<0.001

OS: 总生存期; PFS: 无进展生存期.