急性胰腺炎血浆纤维蛋白相关标志物的动态变化及临床意义

表6 入院后第1、2、3和7天FRMs及其他生化指标对PN的预测

	Cut-offvalue	AUC	95%CI	Sn (%)	Sp (%)	PPV (%)	NPV (%)	Z	P
FM1	5.58	0.595	(0.506, 0.680)	62.50	58.70	39.68	78.26	1.810	0.0703
D-D1	0.86	0.622	(0.537, 0.702)	63.41	62.75	40.62	81.01	2.354	0.0186
LDH1	240.66	0.635	(0.552, 0.712)	66.44	64.76	43.93	82.93	2.620	0.0088
GLU1	8.2	0.629	(0.546, 0.706)	56.82	68.57	40.68	79.42	2.483	0.0130
ALB1	43.15	0.607	(0.523,0.686)	61.36	62.50	40.91	79.27	2.064	0.0390
CRP1	78	0.545	(0.462, 0.627)	27.91	83.96	41.38	74.17	0.854	0.3931
FM2	5.94	0.639	(0.549, 0.723)	60.98	69.41	49.02	78.67	2.711	0.0067
D-D2	1.42	0.590	(0.458, 0.713)	76.19	51.22	44.44	80.77	1.212	0.2256
FDP2	6.23	0.676	(0.548, 0.788)	68.18	66.67	51.73	80.00	2.489	0.0128
LDH2	278.31	0.633	(0.550, 0.711)	31.82	91.26	60.86	75.81	2.569	0.0102
CRP2	102	0.614	(0.530, 0.694)	53.49	68.93	41.81	78.02	2.186	0.0288
FM3	5.87	0.683	(0.590, 0.766)	65.71	67.50	46.93	81.82	3.339	0.0008
D-D3	2.63	0.832	(0.749, 0.896)	77.14	81.58	65.85	88.57	8.422	<0.0001
FDP3	14.09	0.814	(0.731, 0.881)	69.44	83.54	65.78	85.71	7.502	<0.0001
AT-Ⅲ3	81	0.635	(0.551, 0.713)	59.09	68.32	44.82	79.31	2.613	0.0090
LDH3	160.89	0.639	(0.556, 0.717)	88.10	37.50	36.27	88.64	2.754	0.0059
CRP3	105.03	0.706	(0.625, 0.779)	65.91	76.47	54.72	83.37	4.072	<0.0001
FM7	5.87	0.698	(0.596, 0.788)	88.46	52.17	41.07	92.31	3.574	0.0004
D-D7	3.87	0.761	(0.664, 0.841)	65.52	86.96	67.86	85.72	4.371	<0.0001
FDP7	8.79	0.825	(0.735, 0.894)	75.00	82.09	66.66	87.30	6.610	<0.0001
AT-Ⅲ7	94	0.639	(0.552, 0.720)	78.05	45.26	38.10	82.69	2.679	0.0074
LDH7	177.12	0.661	(0.575, 0.740)	78.57	50.00	41.25	83.93	3.182	0.0015
CRP7	42	0.708	(0.624, 0.783)	60.98	81.91	59.52	82.80	3.934	0.0001

FRMs: 纤维蛋白相关标志物; PN: 胰腺坏死; FM: 纤维蛋白单体; D-D: D-二聚体; FDP: 纤维蛋白降解产物; LDH: 乳酸脱氢酶; CRP: C-反应蛋白.