急性胰腺炎血浆纤维蛋白相关标志物的动态变化及临床意义

表5 入院后第1、2和3天FRMs其他生化指标对AP伴POF的预测

	Cut-offvalue	AUC	95%CI	Sn (%)	Sp (%)	PPV (%)	NPV (%)	Z	P
D-D1	1.18	0.693	(0.611, 0.767)	60.00	76.99	40.91	87.88	3.247	0.0012
FDP1	4.63	0.711	(0.629, 0.784)	65.52	70.80	36.53	88.89	3.725	0.0002
LDH1	218.72	0.672	(0.590, 0.747)	82.76	49.58	28.57	92.19	3.528	0.0004
GLU1	8.6	0.720	(0.640, 0.790)	71.87	75.21	42.24	90.72	3.913	0.0001
A1	40.58	0.661	(0.579, 0.737)	53.13	81.90	44.74	86.37	2.725	0.0064
CRP1	84	0.615	(0.532, 0.694)	34.38	86.32	40.74	82.78	2.022	0.0431
D-D2	2.07	0.731	(0.604, 0.836)	73.68	74.42	56.01	86.48	3.357	0.0008
FDP2	10.69	0.755	(0.632, 0.854)	61.11	82.61	57.89	84.21	3.881	0.0001
AT-Ⅲ2	55	0.584	(0.498, 0.666)	25.00	98.25	77.82	84.21	1.330	0.1836
LDH2	261.59	0.761	(0.684, 0.828)	54.84	87.93	54.84	87.93	5.156	<0.0001
CRP2	74.05	0.718	(0.684, 0.828)	83.33	51.72	30.86	92.30	4.446	<0.0001
D-D3	1.94	0.776	(0.687, 0.849)	88.90	61.90	42.85	94.55	5.651	<0.0001
FDP3	15.51	0.769	(0.682, 0.843)	66.67	80.68	51.43	88.75	4.997	<0.0001
AT-Ⅲ3	95	0.664	(0.581, 0.740)	93.33	37.39	28.00	95.55	2.930	0.0034
LDH3	233.64	0.731	(0.651, 0.801)	55.17	82.91	44.45	88.18	4.363	<0.0001
CRP3	203	0.777	(0.506, 0.680)	45.16	95.65	73.67	86.62	6.151	<0.0001

FRMs: 纤维蛋白相关标志物; POF: 伴持续器官功能衰竭; AP: 急性胰腺炎; D-D: D-二聚体; LDH: 乳酸脱氢酶; CRP: C-反应蛋白; FDP: 纤维蛋白降解产物.