四种常见肿瘤标记物联合检测在肝胆系统良恶性疾病中的临床价值

表2 肿瘤标志物在肝胆恶性疾病诊断中的诊断价值

指标	肝脏恶性疾病诊断			胆道恶性疾病诊断
	灵敏度(%)	特异度(%)	正确率(%)	灵敏度(%)	特异度(%)	正确率(%)
AFP	55.36	89.15	83.45	37.37	43.83	32.48
CEA	19.53	75.30	73.47	28.74	66.05	56.39
CA19-9	13.57	66.84	58.86	84.76	70.05	65.59
CA125	48.25	83.05	79.42	46.34	60.37	57.54
AFP+CEA	63.291	72.181	73.211	53.621	40.051	57.741
AFP+CEA+CA19-9	78.342	65.722	57.692	88.772	39.182	76.262
AFP+CEA+CA19-9+CA125	90.273	65.033	56.773	90.443	38.633	84.043

¹肝脏恶性疾病诊断: 与AFP单项检测比较, 灵敏度: AFP+CEA: χ² = 7.27, P = 0.02, AFP+CEA+CA19-9: χ² = 11.05, P = 0.014, AFP+CEA+CA19-9+CA125: χ² = 21.05, P = 0.002; 特异度及正确率: AFP+CEA: χ² = 1.56/1.82, P = 0.58/0.49, AFP+CEA+CA19-9: χ² = 1.05/1.26, P = 0.64/0.66, AFP+CEA+CA19-9+CA125: χ² = 0.87/0.92, P = 0.72/0.70;

²胆道恶性疾病诊断: 与AFP单项检测比较, 灵敏度: AFP+CEA: χ² = 6.88, P = 0.03, AFP+CEA+CA19-9: χ² = 10.82, P = 0.01, AFP+CEA+CA19-9+CA125: χ² = 18.37, P = 0.001;

³特异度及正确率: AFP+CEA: χ² = 2.48/2.35, P = 0.36/0.32, AFP+CEA+CA19-9: χ² = 2.05/1.89, P = 0.42/0.39, AFP+CEA+CA19-9+CA125: χ² = 1.22/1.27, P = 0.58/0.51; AFP: 甲胎蛋白; CEA: 癌胚抗原; CA19-9: 糖链抗原19-9; CA125: 糖链抗原125.