基于RNA-Seq技术的先天性巨结肠转录组学

表3 病变组与正常组差异表达基因显著性富集的通路

序号	通路ID	通路	P值	校正P值	基因数
1	hsa04976	Bile secretion	1.7E-09	2.8E-07	22
2	hsa04974	Protein digestion and absorption	3.0E-09	2.8E-07	23
3	hsa04975	Fat digestion and absorption	3.6E-08	2.2E-06	16
4	hsa00830	Retinol metabolism	2.1E-07	9.8E-06	17
5	hsa04977	Vitamin digestion and absorption	3.2E-07	1.2E-05	11
6	hsa01100	Metabolic pathways	4.1E-07	1.3E-05	121
7	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.4E-06	3.7E-05	17
8	hsa00982	Drug metabolism - cytochrome P450	2.3E-06	5.3E-05	17
9	hsa00140	Steroid hormone biosynthesis	4.1E-06	8.6E-05	14
10	hsa00500	Starch and sucrose metabolism	1.0E-05	1.9E-04	13
11	hsa04973	Carbohydrate digestion and absorption	1.4E-05	2.4E-04	12
12	hsa00591	Linoleic acid metabolism	3.4E-05	5.4E-04	10
13	hsa03320	PPAR signaling pathway	9.6E-05	1.4E-03	15
14	hsa00330	Arginine and proline metabolism	1.1E-04	1.5E-03	13
15	hsa00590	Arachidonic acid metabolism	2.0E-04	2.5E-03	13
16	hsa04614	Renin-angiotensin system	6.6E-04	7.8E-03	6
17	hsa02010	ABC transporters	9.1E-04	1.0E-02	10
18	hsa00910	Nitrogen metabolism	9.9E-04	1.0E-02	7
19	hsa00100	Steroid biosynthesis	1.9E-03	1.8E-02	6
20	hsa00380	Tryptophan metabolism	2.5E-03	2.4E-02	9
21	hsa00051	Fructose and mannose metabolism	4.0E-03	3.6E-02	8
22	hsa00340	Histidine metabolism	4.3E-03	3.7E-02	7
23	hsa04964	Proximal tubule bicarbonate reclamation	5.4E-03	4.4E-02	6
24	hsa04020	Calcium signaling pathway	6.1E-03	4.8E-02	22
25	hsa00360	Phenylalanine metabolism	6.3E-03	4.8E-02	5