慢性乙型肝炎患者临床指标与肝脏纤维化程度关系及明显肝纤维化危险因素的Logistic回归分析

表1 不同肝纤维化分期患者临床指标比较

变量值	S1	S2	S3	S4	P值
年龄(岁)	38.96±9.01	38.63±14.19	42.24±8.70	48.20±8.39	0.093
性别[男, n(%)]	16(64.00)	17(70.83)	13(76.47)	5(50.00)	0.520
HBV DNA(IU/mL)	14400 (499, 2351800)	68725.50 (928.25,3950000)	22813.00 (2054.50, 814000)	63489.50 (499, 89061.25)	0.824
WBC(×109/L)	6.45±1.61	5.21±1.78	5.11±1.70	5.03±2.37	0.036
HB(g/L)	148.20±18.28	147.08±18.54	144.24±17.92	128.90±15.26	0.034
RDW(%)	13.30(12.70,14.00)	13.15(12.93,13.65)	13.60(12.60,14.35)	14.45(14.13,15.18)	0.006
PLT(×109/L)	202.92±53.00	167.25±64.26	136.53±53.31	115.70±56.22	<0.001
MPV(fl)	10.70(10.05,11.85)	10.90(10.15,11.85)	10.80(10.30,12.35)	12.40(11.73,13.45)	0.055
白蛋白(g/L)	42.20(38.45,45.45)	39.65(37.33,43.05)	39.60(35.10,42.80)	37.00(32.95,40.10)	0.026
球蛋白(g/L)	26.68±3.06	27.54±4.74	27.97±4.70	32.43±4.01	0.004
ALT(U/L)	31.00(21.00,44.50)	58.50(34.75,89.00)	51.00(39.00,162.50)	53.00(25.75,85.50)	0.004
AST(U/L)	29.00(26.50,38.50)	42.00(32.25,48.75)	47.00(30.50,103.00)	53.50(41.25,93.25)	0.002
TB(µmol/L)	14.00(9.70,18.45)	15.70(11.48,20.50)	19.90(12.55,29.40)	16.15(13.60,20.10)	0.148
ALP(U/L)	81.24±27.04	91.50±30.30	90.88±29.70	106.40±39.31	0.178
GGT(U/L)	26.36±22.96	55.08±65.19	56.12±58.64	75.90±37.30	0.039
PT(s)	14.24±1.09	14.40±1.61	15.09±1.49	16.04±1.35	0.004

WBC: 白细胞; HB: 血红蛋白; RDW: 红细胞分布宽度; PLT: 血小板计数; MPV: 平均血小板体积; ALT: 谷丙转氨酶; AST: 谷草转氨酶; TB: 总胆红素; ALP: 碱性磷酸酶; GGT: γ-谷氨酰转移酶; PT: 凝血酶原时间.