地塞米松对重症急性胰腺炎肝损伤大鼠EPRS的影响

表3 不同时间点各组之间NF-κB、IFN-γ及血清TNF-α、IL-1β含量比较 (n = 8, mean±SD)

指标	时间	SO组	SAP组	DEX组
NF-κB(ng/L)	2 h	136.025±11.827	133.507±12.274	173.579±37.654
	6 h	138.550±6.328	163.875±18.023a	228.908±13.934a
	12 h	142.925±1.788	133.508±2.644	160.035±38.021
	24 h	135.258±12.842	136.231±17.239	162.559±3.560
IFN-γ(ng/L)	2 h	33.759±2.944	34.781±4.896	37.114±3.503
	6 h	32.505±4.476	77.458±11.280a	60.791±7.943a
	12 h	31.808±4.692	38.393±5.853	35.060±2.564
	24 h	32.505±4.475	32.745±1.966	34.412±2.463
TNF-α(ng/mL)	6 h	0.273±0.914	0.531±0.092a	0.404±0.083a
IL-1β(ng/mL)	6 h	0.163±0.553	0.455±0.048a	0.357±0.067a

^aP<0.05 vs 6 h SO组. SO组: 假手术组; DEX组: 地塞米松组; SAP组: 重症急性胰腺炎组. NF-κB: 核因子κB; IFN-γ: γ-干扰素; TNF-α: 肿瘤坏死因子-α; IL-1β: 白介素-1β.