甲胎蛋白在乙型肝炎病毒诱导肝癌发生中的作用及临床应用展望

表1 人甲胎蛋白部分序列与各种生长因子、转录相关因子保守序列的匹配

Protein	Amino-acidnumbers	Amino-acid sequence	PercentIdentity/Similarity
Growth factors
Human AFP	447-480	L S E D K L L A C G E G A A DI I I G H L C I R H E M T P V N P G V G	100/100
Human TGF-β	106-117	L S E D Q L L L I Q I P	50/8
Human ATV	955-968	L S E Q R L L P R G E G	58/17
Human IL2	1245-1256	I X S I I V G H L G X F	42/8
Transcription-associated factors
Human AFP	339-362	Y S R R H P Q L A V S V I L R V A K G Y Q E L L	100/100
Human RAR	235-254	F A K R L P G F R X G X X L R I A D Q X I T L L	35/40
Human RXR	346-365	W A K R I P H F S X S X X L P L D D Q X V I L L	35/35
Human T3R	286-305	F A K K L P M F C X E X X L P C E D Q X I I L L	20/45
Human ER	360-379	F A K R V P G F V X D X X L R L H D Q X V H L L	25/35
Human AFP	445-457	L S E D K L L A C G E G	100/100
Human HGMP	10-22	L S E D K L L A V A R E	66/8
Human Zn-Fg	725-736	L S D H K L L E S T C K	42/25
Human Rev-erb	523-535	F S E X K L N A L T E E	50/30
Human RAR	307-319	F A N Q X L L X P L E M	30/40
Huamn Coup	305-317	V X E X K L K A L V D S	30/30
Human AFP	458-470	A A D I I I G H L C I R	100/100
Human HGMP	12-21	V A Q I I I G H L C I R	83/7
Human Zn-Fg	330-341	A G G T L V G H L C V R	50/25
Human C-myc	217-226	V Q S I I V G H L C W F	50/17
Human Rb-p	2612-2623	L Q S I I V G H L G C F	42/25
Human Coup	489-502	A A G V A P G H V L R I	33/25
Human AFP	471-480	E M T P V N P G V G	100/100
Human Crumbs	1652-1661	Q W T P V N P G V Q	70/10
Human PAX-3	512-521	I M T P V N P G V P	70/10
Human HOXG2	633-642	E M T P S T P G L Q	60/30
Human TF11D	163-174	P M T P A T P G S A	50/20
Human Src-TK	1280-1289	E M A P I W P G A L	50/20
Human Kid-TS	1145-1154	K S T G A N P G V P	50/10
Human Cad-TS	3718-3727	E M T P V L E A I I	50/0
Human FTZ-F1	628-637	K P T P I S P G Y Q	40/30
Human I-Rel TF	528-537	E A S P S T P G R Q	40/30

AFP: 甲胎蛋白; TGF-β: 转化生长因子β; IL: 白介素; HGMP: 人类基因组图谱制作计划.