普芦卡必利治疗慢性便秘的系统评价

表3 不良事件(普芦卡必利 vs 安慰剂)

不良事件	异质性检验	OR(95%CI)	研究数	n(实验组)	n(对照组)	P值
恶心	0.176	2 mg/d: 2.27(1.59-3.26)	4[18,19,21]	104/518	53/519	0
	0.415	4 mg/d: 2.27(1.58-3.25)	3[18,19,21]	104/520	53/519	0
腹泻	0.992	2 mg/d: 2.72(1.67-4.44)	3[18,19,21]	60/518	24/519	0
	0.453	4 mg/d: 3.40(2.11-5.48)	3[18,19,21]	73/520	24/519	0
腹痛	0.412	2 mg/d: 1.21(0.87-1.67)	3[18,19,21]	98/518	85/519	0.252
	0.622	4 mg/d: 1.22(0.88-1.68)	3[18,19,21]	99/520	85/519	0.227
头痛	0.418	2 mg/d: 2.07(1.49-2.88)	3[18,19,21]	121/518	68/519	0
	0.570	4 mg/d: 2.48(1.79-3.42)	3[18,19,21]	138/520	68/519	0
QT间期延长	0.790	2 mg/d: 1.20(0.32-4.54)	3[18,20,21]	5/450	4/450	0.788
	0.367	4 mg/d: 0.47(0.10-2.07)	3[18,20,21]	1/421	4/450	0.316