抗结核药物肝损伤与无肝损伤患者化疗前血循环miRNA分子的差异性表达

表2 部分miRNA靶基因及其GO生物学功能

序号	miRNA	积分	靶基因	基因全称	GO生物学功能
1	hsa-miR-4800-5p	100	ITGB1BP1	integrin beta 1 binding protein 1	整合素结合蛋白, 细胞黏附功能
2	hsa-miR-4284	99	GNG13	guanine nucleotide binding protein (G protein), gamma 13	水解酶; G蛋白耦联受体蛋白
3	hsa-miR-4284	98	VPS53	vacuolar protein sorting 53 homolog (S. cerevisiae)	线粒体内膜蛋白, 参与脂质代谢过程
4	hsa-miR-4284	98	MAVS	mitochondrial antiviral signaling protein	线粒体信号蛋白
5	hsa-miR-4284	97	ORAI2	ORAI calcium release-activated calcium modulator 2	钙释放激活钙调素
6	hsa-miR-652-5p	94	SEC14L1	SEC14-like 1 (S. cerevisiae)	胆固醇代谢转运/携带蛋白
7	hsa-miR-4284	93	SPN	sialophorin	炎细胞表面糖蛋白, 负调控免疫应答
8	hsa-miR-4284	91	LOC100653346	uncharacterized LOC100653346	功能不清
9	hsa-miR-4284	91	TMEM120B	transmembrane protein 120B	物质代谢过程
10	hsa-miR-4284	90	CYP20A1	cytochrome P450, family 20, subfamily A, polypeptide 1	氧化酶
11	hsa-miR-4284	89	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	线粒体外膜蛋白
12	hsa-miR-4284	89	CDK17	cyclin-dependent kinase 17	非受体丝/苏氨酸蛋白激酶
13	hsa-miR-4284	89	RAB3B	RAB3B, member RAS oncogene family	小分子GTP结合蛋白, RAB家族成员
14	hsa-miR-652-5p	88	SLC25A24	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	线粒体携带因子
15	hsa-miR-4284	88	PLA2R1	phospholipase A2 receptor 1, 180 kDa	磷酯酶A2受体
16	hsa-miR-3620	88	USP46	ubiquitin specific peptidase 46	丝氨酸蛋白酶; 泛素-蛋白质连接酶
17	hsa-miR-3620	87	PUM1	pumilio homolog 1 (Drosophila)	翻译因子
18	hsa-miR-4800-5p	87	DTL	denticleless homolog (Drosophila)	核基质相关蛋白
19	hsa-miR-4284	86	ZNF292	zinc finger protein 292	核酸酶; 转录因子
20	hsa-miR-4284	86	PLIN5	perilipin 5	脂质转运/携带蛋白
21	hsa-miR-4284	86	ENAH	Enabled homolog (Drosophila)	细胞骨架结构成份
22	hsa-miR-4284	85	RAB3IP	RAB3A interacting protein (rabin3)	鸟苷酸交换因子; 信号转导
23	hsa-miR-3620	85	ACPP	acid phosphatase, prostate	磷酯酶
24	hsa-miR-652-5p	83	TLR7	toll-like receptor 7	Toll受体信号通路
25	hsa-miR-652-5p	83	RRAS2	related RAS viral (r-ras) oncogene homolog 2	小GTP酶
26	hsa-miR-3620	83	GPBP1L1	GC-rich promoter binding protein 1-like 1	功能不清
27	hsa-miR-4284	82	RLIM	ring finger protein, LIM domain interacting	E3泛素蛋白连接酶, 可调控细胞迁移
28	hsa-miR-3620	82	INSIG2	insulin induced gene 2	胆固醇代谢过程
29	hsa-miR-4284	82	ZFR2	zinc finger RNA binding protein 2	RNA结合蛋白
30	hsa-miR-652-5p	81	UTS2D	urotensin 2 domain containing	功能不清
31	hsa-miR-652-5p	81	PRKCA	protein kinase C, alpha	非受体丝/苏氨酸蛋白激酶
32	hsa-miR-3620	81	TSPAN9	tetraspanin 9	膜结合信号分子; 受体; 细胞黏附分子
33	hsa-miR-4284	80	AAK1	AP2 associated kinase 1	非受体丝/苏氨酸蛋白激酶