实时组织弹性成像与血清学指标及肝组织活检诊断肝纤维化的临床比较

表2 弹性指数和血清学指标(ng/mL)与肝纤维化各组间比较

指标	S1	S2	S3	S4	χ2值	P值
n	29	23	13	11
LF	2.4(1.8, 2.6)	3.1(2.7, 3.5)b	3.8(3.5, 4.1)bd	5.8(5.4, 6.1)bdf	58.492	0.000
HA	43.1(38.6, 49.6)	66.5(61.8, 8.1)b	98.4(52.9, 103.0)b	98.8(70.7, 110)b	27.934	0.000
LN	81.1(65.1, 103)	70.5(68.8, 78.8)	108.7(102.7, 137)	136.0(52.9, 163.1)bf	16.991	0.001
CⅣ	66.9(39.6, 102.2)	59.0(56.2, 78.0)	56.9(53.6, 91.8)	105.1(79.8, 122.0)adf	10.769	0.013
PCⅢ	96.3(88.4, 100.3)	116.6(94.1, 153.3)b	147.6(114.7, 164.1)b	144.9(126.8, 233.6)bdf	26.144	0.000
PDGF	21.2(19.9, 28.9)	28.3(26.7, 31.3)	28.1(27.4, 29.4)	23.8(23.0, 27.6)d	8.309	0.040
TGF-β1	512.1(429.5, 565.2)	665.4(573, 670.1)b	482.5(398.3, 544.9)d	546.5(518.4, 722.0)	16.936	0.001

^aP<0.05,

^bP<0.01 vs S1组;

^dP<0.01 vs S2组;

^fP<0.01 vs S3组. LF: 肝脏纤维化指数; HA: 透明质酸酶; LN: 层黏连蛋白; PCⅢ : Ⅲ型前胶原; CⅣ: Ⅳ型胶原; PDGF: 小板衍生生长因子; TGF-β1: 转化生长因子β1.