MK-886与塞来昔布小剂量联合对小鼠结肠癌的抑制作用

图2 Western blot法检测MK-866与塞来昔布单独及联合应用小鼠结肠癌瘤组织内ICAM-1和VEGF的蛋白表达变化趋势情况. A: ICAM-actin; B: VEGF-actin. 1: 对照组; 2: MK-866 5 mg/(kg·d)+塞来昔布50 mg/(kg·d); 3: MK-866 5 mg/(kg·d)+塞来昔布100 mg/(kg·d); 4: MK-866 10 mg/(kg·d)+塞来昔布50 mg/(kg·d); 5: MK-866 10 mg/(kg·d)+塞来昔布100 mg/(kg·d). ICAM-1: 细胞间黏附分子-1; VEGF: 血管内皮生长因子.