利用miRNA芯片分析酒精刺激肝癌细胞株miRNA表达谱的差异

表1 miRNA-29b/c靶向TET3 3' UTR区域

预测的相应配对区域: 靶基因(上)和miRNA (下)	种子序列
TET3 3' UTR 53-59	5'	...	C	C	C	G	A	G	C	U	G	U	C	U	C	U	G	U	G	G	U	G	C	U	U	...	3'
																		|	|	|	|	|	|	|
Has-miR-29b	3'	...	U	U	G	U	G	A	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 53-59	5'	...	C	C	C	G	A	G	C	U	G	U	C	U	C	U	G	U	G	G	U	G	C	U	U	...	3'
																		|	|	|	|	|	|	|
Has-miR-29c	3'	...		A	U	U	G	G	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 4472-4479	5'	...	A	G	G	C	U	G	C	U	U	U	U	U	A	G	U	U	G	G	U	G	C	U	A	...	3'
											|	|	|					|	|	|	|	|	|	|
Has-miR-29b	3'	...	U	U	G	U	G	A	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 4472-4479	5'	...	A	G	G	C	U	G	C	U	U	U	U	U	A	G	U	U	G	G	U	G	C	U	A	...	3'
											|	|	|					|	|	|	|	|	|	|
Has-miR-29c	3'	...		A	U	U	G	G	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 1471-1477	5'	...	U	U	U	G	A	A	A	U	G	A	G	A	A	U	G	U	G	G	U	G	C	U	U	...	3'
																		|	|	|	|	|	|	|
Has-miR-29b	3'	...	U	U	G	U	G	A	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 1471-1477	5'	...	U	U	U	G	A	A	A	U	G	A	G	A	A	U	G	U	G	G	U	G	C	U	U	...	3'
																		|	|	|	|	|	|	|
Has-miR-29c	3'	...		A	U	U	G	G	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 3808-3815	5'	...	A	U	A	G	U	C	U	A	A	A	U	A	A	A	A	U	G	G	U	G	C	U	A	...	3'
																		|	|	|	|	|	|	|
Has-miR-29b	3'	...	U	U	G	U	G	A	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'
TET3 3' UTR 3808-3815	5'	...	A	U	A	G	U	C	U	A	A	A	U	A	A	A	A	U	G	G	U	G	C	U	A	...	3'
																		|	|	|	|	|	|	|
Has-miR-29c	3'	...	U	U	G	U	G	A	C	U	A	A	A	G	U	U	U	A	C	C	A	C	G	A	U	...	5'