SELDI-TOF-MS联合LCM技术筛选大肠癌肝转移早期诊断标志蛋白

表1 原发灶癌细胞与正常大肠组织细胞之间差异蛋白数据库搜索结果

差异蛋白质(Da)	Swiss-Prot 代码	等电点	分子量(Da)	蛋白质名称
2735.04	Q9NQX7	6.74	2735	Integral membrane protein 2C precursor
4628.76	O00453-7	9.49	4629	Leukocyte-specific transcript 1 protein (Isoform7)
4676.63	Q07812-3	11.22	4678	Apoptosis regulator Bax (Isoform Gamma)
5386.36	O75771-2	6.52	5387	DNA repair protein RAD51homolog 4 (Isoform2)
6439.23	Q538Z0	9.69	6437	Leucine zipper protein 6
6636.59	O14548	9.77	6636	Cytochrome C oxidase subunit 7A-related protein precursor
7779.19	P78563-5	10.40	7778	Double-stranded RNA-specificeditase1 (Isoform 5)
	Q06643-2	11.71	7780	Tumor necrosis factor C (Isoform 2)
8206.74	O43521-15	5.25	8202	Bcl-2-like protein 11 (Isoform Bim-beta6 )
	Q14508-4	4.24	8214	Human Epididymis Protein 4 (Isoform 4)
9503.81	P35222-2	4.88	9501	Catenin beta-1 (Isoform 2)
10268.06	O95777	4.34	10266	N-alpha-acetyltransferase 38
	P02775	8.94	10271	Platelet basic protein precursor
11740.87	P31949	6.55	11741	Protein S100-A11
12612.62	Q04609-3	8.60	12603	Glutamate carboxypeptidase 2 (Isoform 3 )
	Q13352-3	7.83	12624	Centromere protein R (Isoform 3)
13244. 73	P06702	5.71	13246	Protein S100-A9
21063. 59	P30086	7.43	21057	Raf kinase inhibitor protein(RKIP)
22783. 36	P40198-3	5.97	22783	Heat shock protein 27(HSP-27)