MicroRNA在直肠癌中的表达谱

表2 直肠腺癌与正常直肠黏膜组织表达差异的miRNA

名称	C1	C2	N1	N2	比值	序列
上调
miR-15a	21	28	13	10	2.051	CAGGCCAUAUUGUGCUGCCUCA
miR-18a	2732	5333	705	896	5.039	UAAGGUGCAUCUAGUGCAGAUAG
miR-18a*	116	215	43	28	4.658	ACUGCCCUAAGUGCUCCUUCUGG
miR-21	207	230	70	80	2.903	CAACACCAGUCGAUGGGCUGU
miR-24-2*	138	247	132	54	2.069	UGCCUACUGAGCUGAAACACAG
miR-27a	171	333	128	82	2.406	AGGGCUUAGCUGCUUGUGAGCA
miR-31	2774	610	116	196	10.845	AGGCAAGAUGCUGGCAUAGCU
miR-92a-1*	137	113	41	71	2.230	AGGUUGGGAUCGGUUGCAAUGCU
miR-29b-1*	132	198	55	35	3.649	GCUGGUUUCAUAUGGUGGUUUAGA
miR-106a	12612	20247	7824	8532	2.009	AAAAGUGCUUACAGUGCAGGUAG
miR-7	67	35	20	23	2.379	UGGAAGACUAGUGAUUUUGUUGU
miR-182	3253	1700	652	771	3.480	UUUGGCAAUGGUAGAACUCACACU
miR-183	150	104	44	41	2.980	UAUGGCACUGGUAGAAUUCACU
miR-221	6920	6875	3409	3241	2.074	AGCUACAUUGUCUGCUGGGUUUC
miR-223	123	129	23	44	3.759	UGUCAGUUUGUCAAAUACCCCA
miR-224	115	246	53	29	4.365	CAAGUCACUAGUGGUUCCGUU
miR-224*	251	420	169	149	2.116	AAAAUGGUGCCCUAGUGACUACA
miR-125b-2*	55	62	26	22	2.417	UCACAAGUCAGGCUCUUGGGAC
miR-188	76	166	63	41	2.309	CAUCCCUUGCAUGGUGGAGGG
miR-200c	83	79	43	33	2.118	CGUCUUACCCAGCAGUGUUUGG
miR-135b	20	46	13	13	2.532	AUGUAGGGCUAAAAGCCAUGGG
miR-424	197	268	40	49	5.261	CAAAACGUGAGGCGCUGCUAU
miR-18b	174	336	72	83	3.294	UAAGGUGCAUCUAGUGCAGUUAG
miR-431	40	55	25	16	2.302	UGUCUUGCAGGCCGUCAUGCA
miR-452	59	125	52	31	2.228	AACUGUUUGCAGAGGAAACUGA
miR-181d	154	187	88	52	2.434	AACAUUCAUUGUUGUCGGUGGGU
miR-503	257	404	21	56	8.595	UAGCAGCGGGAACAGUUCUGCAG
miR-509-3p	39	44	15	12	3.035	UGAUUGGUACGUCUGUGGGUAG
miR-552	157	147	86	60	2.077	AACAGGUGACUGGUUAGACAA
miR-584	53	109	46	27	2.219	UUAUGGUUUGCCUGGGACUGAG
miR-550*	153	92	45	34	3.118	UGUCUUACUCCCUCAGGCACAU
miR-622	97	70	37	22	2.814	ACAGUCUGCUGAGGUUGGAGC
miR-421	467	513	148	119	3.666	AUCAACAGACAUUAAUUGGGCGC
miR-542	39	57	21	25	2.076	UCGGGGAUCAUCAUGUCACGAGA
miR-1244	43	74	34	19	2.206	AAGUAGUUGGUUUGUAUGAGAUGGUU
miR-3178	4584	1515	1072	1792	2.130	GGGGCGCGGCCGGAUCG
miR-3200	38	62	24	21	2.226	CACCUUGCGCUACUCAGGUCUG
下调
miR-139-5p	75	95	288	331	0.276	UCUACAGUGCACGUGUCUCCAG
miR-139-3p	26	18	43	82	0.352	GGAGACGCGGCCCUGUUGGAGU
miR-215	393	323	565	955	0.471	AUGACCUAUGAAUUGACAGAC
miR-200b	1279	1071	2271	2827	0.461	UAAUACUGCCUGGUAAUGAUGA
miR-133a	28	36	61	99	0.405	UUUGGUCCCCUUCAACCAGCUG
miR-150	1892	820	2894	3659	0.414	UCUCCCAACCCUUGUACCAGUG
miR-195	1669	2106	5301	4240	0.396	UAGCAGCACAGAAAUAUUGGC
miR-194*	565	390	573	1364	0.493	CCAGUGGGGCUGCUGUUAUCUG
miR-375	1490	1099	6325	6195	0.207	UUUGUUCGUUCGGCUCGCGUGA
miR-378*	207	171	613	546	0.326	CUCCUGACUCCAGGUCCUGUGU
miR-378	4194	3168	9494	10281	0.372	ACUGGACUUGGAGUCAGAAGG
miR-342	124	96	264	199	0.477	AGGGGUGCUAUCUGUGAUUGA
miR-133b	22	25	42	59	0.469	UUUGGUCCCCUUCAACCAGCUA
miR-422a	583	573	2067	1291	0.344	ACUGGACUUAGGGUCAGAAGGC
miR-574	3042	2515	4567	7373	0.465	CACGCUCAUGCACACACCCACA
miR-650	91	121	179	306	0.438	AGGAGGCAGCGCUCUCAGGAC
miR-378c	1855	1442	4579	3743	0.396	ACUGGACUUGGAGUCAGAAGAGUGG
miR-4281	642	700	996	1766	0.486	GGGUCCCGGGGAGGGGGG