2型糖尿病中国地鼠脂肪肝相关胰岛素抵抗的形成机制

表3 胰岛素抵抗地鼠和2型糖尿病地鼠肝脏中基因表达芯片显示的部分与糖脂代谢相关的差异表达基因

序列号	基因名称	胰岛素抵抗组(倍数变化)	2型糖尿病组(倍数变化)	调解者1
NM_007988	fatty acid synthase (Fasn)	2.26	3.99	SREBP-1
BE865030	acetyl-Coenzyme A carboxylase (ACC)	2.04	3.33	SREBP-1
NM_009127	Stearoyl CoA desaturase 1(Scd1)	2.57	4.27	SREBP-1
NM_053115	acyl-Coenzyme A oxidase	-1.99	-2.66	PPARα
NM_013495	carnitine palmitoyltransferase 1, liver (Cpt1)	-1.90	-2.60	PPARα
NM_007382	acetyl-Coenzyme A dehydrogenase, medium chain (Acadm)	-2.09	-2.75	PPARα
NM_007824	cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1)	-2.00	-3.02	LXRα
BM937289	3-hydroxy-3-methylglutaryl-coenzyme A reductase(Hmgcr)	2.03	3.02	SREBP-2
NM_145942	3-hydroxy-3-methylglutaryl-Coenzyme A synthase (Hmgcs)	1.72	3.83	SREBP-2
NM_010700	low density lipoprotein receptor (Ldlr)	1.97	2.87	SREBP-2
NM_007643	CD36 antigen (Cd36) CD36/ FAT	2.02	3.31	PPARγ
NM_010292	glucokinase (Gck)	-2.05	-2.99	LXRα
NM_008061	glucose-6-phosphatase, catalytic (G6pc)	1.89	2.37	LXRα
NM_011044	phosphoenolpyruvate carboxykinase 1, cytosolic (Pck1)	1.90	3.61	LXRα
NM_011480	sterol regulatory element binding factor 1 (Srebf1)	2.76	3.72	LXRα
XM_127995	sterol regulatory element binding factor 2 (Srebf2)	2.65	3.38
NM_013839	nuclear receptor subfamily 1, group H, member 3 (Nr1h3)	-2.07	-2.80	LXRα
NM_009473	nuclear receptor subfamily 1, group H, member 2 (Nr1h2)	NC	NC
NM_011144	peroxisome proliferator activated receptor alpha (Ppara)	-2.13	-3.14
NM_011145	peroxisome proliferator activator receptor delta (Ppard)	-2.03	-2.82
NM_011146	peroxisome proliferator activated receptor gamma (Pparg)	2.18	2.91
NM_008509	lipoprotein lipase (Lpl)	2.06	3.79	PPARγ
NM_024406	fatty acid binding protein 4, adipocyte (Fabp4), aP2	2.17	3.87	PPARγ
NM_008904	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Ppargc1a)	2.20	3.21	LXRα

¹在后续研究中确定基因的主要调解者. NC表示无变化.