戊己丸不同配比方对大鼠体外CYP1A2酶活性的影响

表4 戊己丸提取物组方对CYP1A2酶活性影响的L₉(3⁴)正交t值法计算结果 (mean±SD, n = 6)

统计项	黄连	制吴茱萸	炒白芍	t值
M1	483.58	166.85	169.80	t(0.05, 45) = 2.0145
M2	183.73	224.88	166.00	t(0.01, 45) = 2.6910
M3	146.62	422.2	478.13	t(0.001, 45) = 3.5235
D1-2	299.85	-58.03	3.80
D2-3	37.11	-197.32	-312.13
D1-3	336.96	-255.35	-308.33
t1-2	28.0769	5.4337	0.3558
t2-3	3.4748	18.4763	29.2267
t1-3	31.5517	23.9101	28.8709
P1-2	[t = 28.0769>3.5235]d	[t = 5.4337＞3.5235]d	t = 0.3558<2.0145
P2-3	[t = 3.4748>2.6910]b	[t = 18.4763>3.5235]d	[t = 29.2267>3.5235]d
P1-3	[t = 31.5517>3.5235]d	[t = 23.9101>3.5235]d	[t = 28.8709>3.5235]d

M₁、M₂、M₃: 分别是该列药物低、中、高剂量IC₅₀值之和; D_1-2是M₁与M₂极差; D_2-3是M₂与M₃极差; D_1-3是M1与M3极差.

^bP<0.01,

^dP<0.001.