肥胖与大肠腺瘤关系的临床及分子机制

表4 肥胖组较正常组表达上调基因和下调基因

因子	全称	正常组标准值	肥胖组标准值	肥胖标/正常标
ATF2	Activating transcription factor 2	1.8204E-3	5.3992E-3	2.9658E+01
BAX	BCL2-associated X protein	7.4304E-5	3.5237E-3	4.7422E+11
BCL2	B-cell CLL/lymphoma 2	2.3220E-3	5.4181E-3	2.3334E+01
FN1	Fibronectin 1	3.0747E-1	6.9380E-1	2.2565E+01
FOXA2	Forkhead box A2	1.1944E-2	5.8879E-2	4.9295E+01
KLK3	Kallikrein-related peptidase 3	3.5870E-2	8.7220E-2	2.4315E+01
BCL2L1	BCL2-like 1	3.4914E-1	1.4864E-1	4.2573E-12
NAIP	NLR family, apoptosis inhibitory protein	8.7864E-3	4.2057E-3	4.7865E-12
CCND1	Cyclin D1	7.8669E-2	3.2603E-2	4.1444E-12
CXCL9	Chemokine (C-X-C motif) ligand 9	3.1473E-1	1.2994E-1	4.1286E-12
EN1	Engrailed homeobox 1	1.1108E-2	4.9066E-3	4.4170E-12
IL1α	Interleukin 1, alpha	5.5022E-2	1.7448E-2	3.1711E-12
IL2RA	Interleukin 2 receptor, alpha	4.7090E-2	6.5548E-3	1.3920E-12
IL4	Interleukin 4	1.9040E-2	6.7821E-3	3.5620E-12
IL8	Interleukin 8	7.8034E-1	1.4638E-1	1.8759E-1
LEP	Leptin (obesity homolog, mouse)	2.6489E-2	1.2143E-2	4.5843E-12
MMP10	Matrix metallopeptidase 10 (stromelysin 2)	1.5760E-1	6.4676E-2	4.1039E-12
MYC	V-myc myelocytomatosis viral	7.7896E-1	3.1393E-1	4.0301E-12
	oncogene homolog (avian)
PTGS2	Prostaglandin-endoperoxide synthase 2	2.8923E-2	6.3653E-3	2.2008E-12
	(prostaglandin G/H synthase and cyclooxygenase)
RBBP8	Retinoblastoma binding protein 8	7.0403E-2	2.0555E-2	2.9196E-12
RBP1	Retinol binding protein 1, cellular	4.4285E-2	1.8433E-2	4.1623E-12
RBP2	Retinol binding protein 2, cellular	8.8997E-2	2.1009E-2	2.3607E-12
WISP1	WNT1 inducible signaling pathway protein 1	7.2911E-2	3.4725E-2	4.7627E-12

¹上调基因, 肥胖标/正常标≥2;

²下调基因, 肥胖标/正常标≤0.5.