移植雄性骨髓的雌性小鼠肝组织肝再生相关基因的信号通路

表1 肝再生相关信号通路差异表达基因

通路名称	信号比值	Gene-symbol	Gene-description
Apoptosis	0.367	NFKB2	Nuclear factor of kappa light polypeptidegene enhancer in B-cells 2, p49/p100
	2.951	MAP3K14	Mitogen-activated protein kinase kinase kinase 14
	2.733	PIK3RL	Phosphatidylinositol 3-kinase, regulatory subunit,
			polypeptide 1(p85 alpha)
Cytokine-cytokine receptor	0.481	BMP2	Bone morphogenetic protein 2
interaction	0.25	TGFβ2	Transforming growth factor, beta 2
	2.136	HGF	Hepatocyte growth factor
	2.001	VEGFC	Vascular endothelial growth factor C
	0.231	IL12Rβ2	nterleukin 12 receptor, beta 2
	2.001	CSF3R	Colony stimulating factor 3 receptor (granulocyte)
	2.026	IL6Rα	Interleukin 6 receptor, alpha
	0.493	IL13	Interleukin 13
	2.05	NGFR	Nerve growth factor receptor
Jak-Stat signaling pathway	2.733	PIK3RL	Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1(p85 alpha)
	2.001	CSF3R	Colony stimulating factor 3 receptor(granulocyte)
	0.231	IL12Rβ2	Interleukin 12 receptor, beta 2
	2.026	IL6Rα	Interleukin 6 receptor, alpha
	0.493	IL13	Interleukin 13
MAPK signaling pathway	0.475	PPM1B	Protein phosphatase 1B, Magnesium dependent, beta isoform
	0.298	PLA2GIB	Phospholipase A2, group IB, pancreas
	0.367	NFKB2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
	2.951	MAP3K14	Mitogen-activated protein kinase kinasekinase 14
	0.463	PRKCβ	Protein kinase C, beta
	0.442	MAP3K6	Mitogen-activated protein kinase kinase kinase 6
	0.25	TGFβ2	Transforming growth factor, beta 2
	0.376	MAPK8IP2	Mitogen-activated protein kinase 8 interacting protein 2
	0.238	HSPA5	Heat shock 70 kDa protein 5(glucose-regulated protein, 78 kDa)
	0.338	HSPA8	Heat shock 70 kDa protein 8
	0.35	HSPA1l	Heat shock 70 kDa protein 1-like
	0.263	FOS	FBJ osteosarcoma oncogene
TGF-beta signaling pathway	0.25	TGFβ2	Transforming growth factor, beta 2
	0.429	DCN	Decorin
	0.481	BMP2	Bone morphogenetic protein 2
	0.429	BMP4	Bone morphogenetic protein 4
Toll-like receptor signaling	0.367	NFKB2	Nuclear factor of kappa light polypeptidegene enhancer in
pathway			B-cells 2, p49/p100
	0.263	FOS	FBJ osteosarcoma oncogene
	0.395	TIRAP	Toll-interleukin 1 receptor(TIR)domain-containing adaptor protein
	2.733	PIK3RL	Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1(p85 alpha)
WNT signaling pathway	0.463	PRKCβ	Protein kinase C, beta
	0.479	WNT4	Wingless-related MMTV integration site 4
	0.332	FOSL1	Fos-like antigen 1
	2.357	CSNK1α1	Casein kinase 1, alpha 1
	0.436	2410091N08RIK	RIKEN cDNA 2410091N08 gene
	0.334	FRATL	Frequently rearranged in advanced T-cell lymphomas
	0.263	CSNKLE	Casein kinase 1, epsilon
	0.262	LRP5	Low density lipoprotein receptor-related protein 5